Results 61 to 70 of about 4,910 (136)

Formulation and Pharmacological Evaluation of a Medicine‐Food Homology Herb‐Based Formula for Sleep Enhancement

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
This outlines the progress for developing a sleep‐modulating herbal formula (SMF). It begins with the identification of effective compounds and quality control, then uses network pharmacology and molecular docking to explain the mechanisms behind the observation found on the behavioural and neurobiological results in animal study.
Jasmine U. Ting, Chunxue Zhao, Jia Xu, Chenrui Liu, Yungang Tian, Min Ye, Tao Cui, Jian Huang   +7 more
wiley   +1 more source

Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders

Frontiers in Endocrinology, 2019
Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored ...
Marcia H. Ratner, Vidhya Kumaresan, David H. Farb   +2 more
doaj   +1 more source

The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder

Frontiers in Pharmacology, 2018
The translocator protein (18 kDa) (TSPO) recently attracted increasing attention in the pathogenesis of post-traumatic stress disorder (PTSD). This study is testing the hypothesis that the overexpression of TSPO in hippocampus dentate gyrus (DG) could ...
Xiao-Ying Zhang, Xiao-Ying Zhang, Wang Wei, You-Zhi Zhang, Qiang Fu, Wei-Dong Mi, Li-Ming Zhang, Yun-Feng Li   +7 more
doaj   +1 more source

Reduced Neurosteroid Exposure Following Preterm Birth and Its’ Contribution to Neurological Impairment: A Novel Avenue for Preventative Therapies

Frontiers in Physiology, 2019
Children born preterm are at an increased risk of developing cognitive problems and neuro-behavioral disorders such as attention deficit hyperactivity disorder (ADHD) and anxiety. Whilst neonates born at all gestational ages, even at term, can experience
Julia C. Shaw, Julia C. Shaw, Mary J. Berry, Mary J. Berry, Rebecca M. Dyson, Rebecca M. Dyson, Gabrielle K. Crombie, Gabrielle K. Crombie, Jonathan J. Hirst, Jonathan J. Hirst, Hannah K. Palliser, Hannah K. Palliser   +11 more
doaj   +1 more source

Zuranolone therapy protects frontal cortex neurodevelopment and improves behavioral outcomes after preterm birth

Brain and Behavior
Background Preterm birth is associated with brain injury and long‐term behavioral abnormalities, for which there are limited prevention options. When born preterm, infants prematurely lose placental neurosteroid (allopregnanolone) support. This increases
Roisin A. Moloney, Hannah K. Palliser, Carlton L. Pavy, Julia C. Shaw, Jonathan J. Hirst   +4 more
doaj   +1 more source

Animal models of catamenial epilepsy: Discovery of an extrasynaptic molecular mechanism for targeted therapy

Frontiers in Cellular Neuroscience, 2016
Catamenial epilepsy is a complex neuroendocrine condition in which seizures are clustered around specific points in the menstrual cycle, most often around perimenstrual or periovulatory period.
Doodipala Samba eReddy
doaj   +1 more source

Estradiol synthesis and action at the synapse: evidence for ‘synaptocrine’ signaling

Frontiers in Endocrinology, 2011
Classically, the modulation of brain function and behavior by steroid hormones was linked exclusively to secretion by peripheral endocrine glands. Subsequently, steroid actions within the brain were shown dependent upon either synthesis and secretion by ...
Luke eRemage-Healey, Colin J Saldanha, Barney A Schlinger   +2 more
doaj   +1 more source

Allopregnanolone and mood in the peripartum: a longitudinal assessment in healthy women

Frontiers in Behavioral Neuroscience
BackgroundAllopregnanolone (ALLO), a neuroactive steroid hormone derived from progesterone, can modulate mood via the GABA-A receptor. Peripartum mood can be influenced by psychosocial factors, previous mental illness, and hormonal changes.
Maria Katharina Grötsch, Ulrike Ehlert
doaj   +1 more source

Divergent Mechanisms of Antidepressant Efficacy: A Unified Computational Comparison of Synaptogenesis, Stabilization, and Tonic Inhibition in a Model of Depression. [PDF]

Cureus
Cheung N.
europepmc   +1 more source

5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes. [PDF]

NeuroSci
Rodriguez-Cerdeira C.
europepmc   +1 more source