Results 51 to 60 of about 4,910 (136)

DEHYDROEPIANDROSTERONE BIOSYNTHESIS, ROLE AND MECHANISM OF ACTION IN THE DEVELOPING NEURAL TUBE.

Frontiers in Endocrinology, 2012
Dehydroepiandrosterone (DHEA) is synthesized from cholesterol by activity of P450scc and P450c17, enzymes that we previously characterized in the developing nervous system.
mark eGaldo, Christelle S Fiore, Jennifer eGregonis, Nathalie A Compagnone, Nathalie A Compagnone   +4 more
doaj   +1 more source

Pineal Neurosteroids: Biosynthesis and Physiological Functions

Frontiers in Endocrinology, 2020
Similar to the adrenal glands, gonads, and placenta, vertebrate brains also produce various steroids, which are known as “neurosteroids.” Neurosteroids are mainly synthesized in the hippocampus, hypothalamus, and cerebellum; however, it has recently been
Shogo Haraguchi, Kazuyoshi Tsutsui
doaj   +1 more source

Defining the end point of status epilepticus: A scoping review and framework for standardization

Epilepsia, Volume 67, Issue 6, Page 2673-2688, June 2026.
Abstract Status epilepticus (SE) is a life‐threatening neurological emergency with consensus‐driven definitions for onset but no standardized criteria for its end point. This gap creates uncertainty in research and clinical practice. We conducted a scoping review to evaluate how end points have been defined in SE research and to identify key areas of ...
Fawad A. Khan, Margaret T. Gopaul, Samuel L. Carter, Anil Chimakurthy, Summer Skelton, Lawrence J. Hirsch, Eugen Trinka   +6 more
wiley   +1 more source

Women with epilepsy: Evidence‐based counseling across the lifespan

Epilepsia, Volume 67, Issue 6, Page 2689-2706, June 2026.
Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn, Georgia Ramantani, Dominique Flügel, Verena Gaus, Susanne Schubert‐Bast, Elisabeth Sellitto, Jennifer Bausch, Bettina Schmitz   +7 more
wiley   +1 more source

Allopregnanolone and Neuroinflammation: a Focus on Multiple Sclerosis

Frontiers in Cellular Neuroscience, 2014
The progesterone derivative, allopregnanolone (ALLO), is one of the most widely studied compounds among neurosteroids. Through interactions with GABA-A receptors expressed by neurons and glial cells, ALLO has been shown to affect diverse aspects of ...
Farshid eNoorbakhsh, Glen B Baker, Christopher ePower   +2 more
doaj   +1 more source

An iEEG investigation on sex‐specific differences in seizure duration

Epilepsia Open, Volume 11, Issue 3, Page 912-921, June 2026.
Abstract Objective Male people with epilepsy (mPWE) are at higher risk for bilateral tonic–clonic seizures (BTCs) and sudden unexpected death in epilepsy (SUDEP) compared to female people with epilepsy (fPWE). Despite major clinical and personal implications, little is known about sex‐specific differences in seizure propagation and termination ...
Paula Albert I Gracenea, Alexandra Muss, Magdalena Seethaler, Jan Rémi, Elisabeth Kaufmann   +4 more
wiley   +1 more source

Androgen Regulation of the Mesocorticolimbic System and Executive Function

Frontiers in Endocrinology, 2018
Multiple lines of evidence indicate that androgens, such as testosterone, modulate the mesocorticolimbic system and executive function. This review integrates neuroanatomical, molecular biological, neurochemical, and behavioral studies to highlight how ...
Daniel J. Tobiansky, Daniel J. Tobiansky, Kathryn G. Wallin-Miller, Stan B. Floresco, Stan B. Floresco, Ruth I. Wood, Kiran K. Soma, Kiran K. Soma, Kiran K. Soma   +8 more
doaj   +1 more source

Psychosocial and menstrual correlates of premenstrual disorders: A community‐based study

International Journal of Gynecology &Obstetrics, Volume 173, Issue 3, Page 1472-1479, June 2026.
Abstract Objective To assess the background, psychosocial, and menstrual factors associated with premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) in a community‐based cohort. Methods A prospective cohort study was conducted using data from users of a menstrual tracking application.
Shiori Itoi, Makiko Sampei, Takayuki Tatsumi, Yutaka Osuga, Kaori Koga, Satoshi Narumi, Naho Morisaki   +6 more
wiley   +1 more source

Mitigation of Cisplatin‐Induced Neurotoxicity via Nrf2/HO‐1 Signaling and Autophagy: The Protective Role of Vitamin D

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This study investigates the neuroprotective effect of vitamin D against cisplatin‐induced mitochondrial damage and oxidative stress (ROS). HO‐1 expression is increased by vitamin D, which triggers Nrf2 activation and nuclear translocation. The results demonstrate that vitamin D protects brain tissue by strengthening the antioxidant defense system ...
Songul Cuglan, Azibe Yildiz, Kevser Tanbek   +2 more
wiley   +1 more source

Steroidogenic acute regulatory (StAR) protein expression in the central nervous system

Frontiers in Endocrinology, 2011
Locally produced neurosteroids are proposed to have many functions in the central nervous system. The identification of the steroidogenic acute regulatory (StAR) protein in steroid-producing neural cells provides a new tool to understand the sites ...
Steven R. King, Douglas M Stocco
doaj   +1 more source