Results 21 to 30 of about 5,061 (119)

Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif

Frontiers in Pharmacology, 2018
Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of N-methyl-D-aspartate receptors (NMDARs) receptors that employ an amide structural motif, relative to pregnanolone glutamate ...
Santosh Kumar Adla, Barbora Slavikova, Hana Chodounska, Vojtech Vyklicky, Marek Ladislav, Pavla Hubalkova, Barbora Krausova, Tereza Smejkalova, Michaela Nekardova, Michaela Nekardova, Marketa Smidkova, Lenka Monincova, Radko Soucek, Ladislav Vyklicky, Eva Kudova   +14 more
doaj   +1 more source

The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy

Frontiers in Pharmacology, 2022
In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy.
Makoto Ishikawa, Makoto Ishikawa, Toru Nakazawa, Toru Nakazawa, Toru Nakazawa, Toru Nakazawa, Hiroshi Kunikata, Hiroshi Kunikata, Kota Sato, Kota Sato, Takeshi Yoshitomi, Takeshi Yoshitomi, Kathiresan Krishnan, Douglas F. Covey, Douglas F. Covey, Douglas F. Covey, Douglas F. Covey, Charles F. Zorumski, Charles F. Zorumski, Charles F. Zorumski, Yukitoshi Izumi, Yukitoshi Izumi, Yukitoshi Izumi   +22 more
doaj   +1 more source

Alfaxalone Causes Reduction of Glycinergic IPSCs, but Not Glutamatergic EPSCs, and Activates a Depolarizing Current in Rat Hypoglossal Motor Neurons

Frontiers in Cellular Neuroscience, 2019
We investigated effects of the neuroactive steroid anesthetic alfaxalone on intrinsic excitability, and on inhibitory and excitatory synaptic transmission to hypoglossal motor neurons (HMNs).
Cora Lau, Prajwal P. Thakre, Mark C. Bellingham   +2 more
doaj   +1 more source

Reduced Levels of Neurosteroids in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients

Biomolecules
Produced by the mitochondria and endoplasmic reticulum, neurosteroids such as allopregnanolone are neuroprotective molecules that influence various neuronal functions and regulate neuroinflammation.
Chiara Lucchi, Cecilia Simonini, Cecilia Rustichelli, Rossella Avallone, Elisabetta Zucchi, Ilaria Martinelli, Giuseppe Biagini, Jessica Mandrioli   +7 more
doaj   +1 more source

Investigating the Synergistic Effect of Palmitoylethanolamide and Ganaxolone in PTZ-induced Tonic-clonic Seizures

مجله علمی دانشگاه علوم پزشکی کردستان, 2023
Background and Aim: Anticonvulsive effects of neurosteroids were shown in animal models. Endocannabinoids modulate neuronal excitability. In this study, we investigated the synergism of the simultaneous application of Palmitoylethanolamide (PEA) as an ...
Hesamodin Bagheripoor, Abbas Alimoradian, Mehdi Sadegh   +2 more
doaj  

Measurement of steroid concentrations in brain tissue: methodological considerations

Frontiers in Endocrinology, 2011
It is well recognized that steroids are synthesized de novo in the brain (neurosteroids). In addition, steroids circulating in the blood enter the brain.
Matthew D Taves, Matthew D Taves, Chunqi eMa, Sarah A Heimovics, Colin J Saldanha, Colin J Saldanha, Kiran K Soma, Kiran K Soma, Kiran K Soma   +8 more
doaj   +1 more source

Combined liquid and solid-phase extraction improves quantification of brain estrogen content

Frontiers in Neuroanatomy, 2011
Accuracy in quantifying brain-derived steroid hormones (‘neurosteroids’) has become increasingly important for understanding the modulation of neuronal activity, development, and physiology.
Andrew eChao, Andrew eChao, Barney A Schlinger, Luke eRemage-Healey, Luke eRemage-Healey   +4 more
doaj   +1 more source

Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis

Cells, 2020
Neurosteroids are steroids synthetized in the nervous system, with the first step of steroidogenesis taking place within mitochondria with the synthesis of pregnenolone. They exert important brain-specific functions by playing a role in neurotransmission,
Melissa Witzig, Amandine Grimm, Karen Schmitt, Imane Lejri, Stephan Frank, Steven A. Brown, Anne Eckert   +6 more
doaj   +1 more source

Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes

Pharmacology Research & Perspectives, 2022
The translation of new injectable anesthetic drugs from rodent to humans remains slow, despite the realization that reliance on the volatile agents is unsustainable from an environmental perspective. The aim of this study was to investigate the influence
Kate White, Mohammed Aldurdunji, John Harris, Catherine Ortori, Stuart Paine   +4 more
doaj   +1 more source

Microglial Cell Morphology and Phagocytic Activity Are Critically Regulated by the Neurosteroid Allopregnanolone: A Possible Role in Neuroprotection

Cells, 2021
Microglial cells are key players in neural pathogenesis and microglial function regulation appears to be pivotal in controlling neuroinflammatory/neurological diseases.
Valérie Jolivel, Susana Brun, Fabien Binamé, Jérémie Benyounes, Omar Taleb, Dominique Bagnard, Jérôme De Sèze, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan   +8 more
doaj   +1 more source