Results 81 to 90 of about 4,624 (175)

Overview of the Molecular Steps in Steroidogenesis of the GABAergic Neurosteroids Allopregnanolone and Pregnanolone

Chronic Stress, 2018
Allopregnanolone and pregnanolone—neurosteroids synthesized from progesterone in the brain, adrenal gland, ovary and testis—have been implicated in a range of neuropsychiatric conditions including seizure disorders, post-traumatic stress disorder, major ...
Jennifer J. Liang, Ann M. Rasmusson
doaj   +1 more source

Animal Models of PTSD: The Socially Isolated Mouse and the Biomarker Role of Allopregnanolone

Frontiers in Behavioral Neuroscience, 2019
Post-traumatic stress disorder (PTSD) is a debilitating undertreated condition that affects 8%–13% of the general population and 20%–30% of military personnel.
Graziano Pinna
doaj   +1 more source

Allopregnanolone suppresses diabetes-induced neuropathic pain and motor deficit through inhibition of GABAA receptor down-regulation in the spinal cord of diabetic rats [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s):Painful diabetic neuropathy is associated with hyperexcitability and hyperactivity of spinal cord neurons. However, its underlying pathophysiological mechanisms have not been fully clarified.
Samira Afrazi, Saeed Esmaeili-Mahani
doaj  

Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models

Scientific Reports, 2017
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple tics and sensorimotor abnormalities, the severity of which is typically increased by stress.
Laura J. Mosher, Sean C. Godar, Marianela Nelson, Stephen C. Fowler, Graziano Pinna, Marco Bortolato   +5 more
doaj   +1 more source

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Frontiers in Cellular Neuroscience
The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological ...
Keiko Takasu, Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Koichi Ogawa   +7 more
doaj   +1 more source

Differential effects of allopregnanolone and diazepam on social behavior through modulation of neural oscillation dynamics in basolateral amygdala and medial prefrontal cortex

Frontiers in Cellular Neuroscience
Effective treatments for major depressive disorder (MDD) have long been needed. One hypothesis for the mechanism of depression involves a decrease in neuroactive steroids such as allopregnanolone, an endogenous positive allosteric modulator of the γ ...
Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Keiko Takasu, Koichi Ogawa   +7 more
doaj   +1 more source

Author's Response: Allopregnanolone Assays [PDF]

Journal of Clinical Endocrinology & Metabolism, 2001
openaire   +1 more source

The neurosteroid paradigm in perinatal depression: From pathophysiology to precision therapeutics. [PDF]

J Neuroendocrinol
Radonjić NV, Moon KC, Deligiannidis KM.
europepmc   +1 more source

Update on psychoneuroimmunoendocrinology. [PDF]

World Psychiatry
Tafet GE, Nemeroff CB.
europepmc   +1 more source

Distinct Modulation of High- and Low-Frequency Activity by Midazolam and Neurosteroids in Neocortical Slices. [PDF]

Int J Mol Sci
Bieletzki S, Gotthard C, Puig-Bosch X, Zeilhofer HU, Rudolph U, Rammes G, Antkowiak B, Drexler B.   +7 more
europepmc   +1 more source