Results 91 to 100 of about 6,010 (206)

Allopregnanolone and progesterone in relation to a single electroconvulsive therapy seizure and subsequent clinical outcome: an observational cohort study

BMC Psychiatry
Background Electroconvulsive therapy (ECT) is an important treatment for several severe psychiatric conditions, yet its precise mechanism of action remains unknown.
Elin Thörnblom, Janet L. Cunningham, Malin Gingnell, Mikael Landén, Jonas Bergquist, Robert Bodén   +5 more
doaj   +1 more source

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Neurobiology of Stress, 2019
The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials of a related neuroactive steroid, SGE-217, for men and women with major depressive disorder offer the ...
Charles F. Zorumski, Steven M. Paul, Douglas F. Covey, Steven Mennerick   +3 more
doaj   +1 more source

Allopregnanolone in postpartum depression: Role in pathophysiology and treatment

Neurobiology of Stress, 2020
Postpartum depression (PPD) is a unique subtype of major depressive disorder and a substantial contributor to maternal morbidity and mortality. In addition to affecting the mother, PPD can have short- and long-term consequences for the infant and partner.
Samantha Meltzer-Brody, Stephen J. Kanes
doaj   +1 more source

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto, Javier Valero‐Ochando, Rosa López‐Pedrajas, Teresa Olivar, Vicente Hernández‐Rabaza, Inmaculada Almansa, María Miranda   +6 more
wiley   +1 more source

Novel analogs of allopregnanolone show improved efficiency and specificity in neuroprotection and stimulation of proliferation. [PDF]

, 2016
The natural neurosteroid allopregnanolone exerts beneficial effects in animal models of neurodegenerative diseases, nervous system injury and peripheral neuropathies.
Hofmann, Hans-Dieter, Kirsch, Matthias, Karout, Mona, Kraft, Stephanie, Geoffroy, Philippe, Mensah-Nyagan, Ayikoé-Guy, Miesch, Michel, Mensah-Nyagan, Ayikoe Guy   +7 more
core   +1 more source

Antioxidant and Anti-Apoptotic Properties of Allopregnanolone in Protecting Dopaminergic Neurons from 6-OHDA-Induced Injury [PDF]

Veterinary and Comparative Biomedical Research
Dopaminergic neurodegeneration is associated with oxidative stress, mitochondrial dysfunction, neuroinflammation, and cell death. Allopregnanolone, a multifunctional neurosteroid, is involved in various biological processes within the body.
Hossein Khodadadi, Hossein Jonaidi, Saeed Esmaeili-Mahani, Mehran Pourmashayekhi, Parsa Jonaidi   +4 more
doaj   +1 more source

Arcuate nucleus‐specific progesterone receptor knockdown in female mice is sufficient to induce PCOS‐like hyperactivity in the reproductive axis

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract Mammalian reproductive function is dependent upon gonadal steroid hormone feedback within the hypothalamic–pituitary–gonadal (HPG) axis. In polycystic ovary syndrome (PCOS), impaired progesterone (P4) negative feedback leads to hyperactive pulsatile secretion of luteinising hormone (LH) and impaired reproductive function.
Kelly A. Glendining, Melanie Prescott, Kyoko Potapov, Elodie Kip, Rebecca E. Campbell   +4 more
wiley   +1 more source

Serum allopregnanolone levels in pregnant women: changes during pregnancy, at delivery and in hypertensive patients [PDF]

, 2000
Allopregnanolone is a neuroactive steroid measurable in peripheral circulation. The aim of the present study was to investigate the presence and the possible changes in serum allopregnanolone and progesterone levels in pregnant women during gestation, at
NAPPI, R. E., BENEDETTO, C., Bernardi F, NAPPI, ROSSELLA, REIS, F. M., GENAZZANI, A. R., PETRAGLIA, F., FADALTI, M., Nappi RE, Petraglia F, Genazzani AR, BERNARDI, F., LUISI, S., Fadalti M, GENAZZANI, ANDREA, Luisi S, Benedetto C, LUISI, M., Luisi M, Reis FM   +19 more
core   +1 more source

Refractory Status Epilepticus Treated With Bilateral Pulvinar Deep Brain Stimulation—A Case Study

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 627-632, March 2026.
ABSTRACT New‐onset refractory status epilepticus (NORSE) arises without an identifiable cause or prior epilepsy history, with a 16%–27% mortality rate and significant long‐term neurological sequelae. Neuromodulation such as deep brain stimulation (DBS) targeting the anterior and centromedian thalamic nuclei has shown promise when the traditional ...
Mengxuan Tang, Amerta Bai, Felipe Rodridgues Marques Ferreira, Sandipan Pati, Thaddeus Walczak, Benjamin Miller, Oladi Bentho, Thomas Henry, Ilo Leppik, Minoo Shams, Zhiyi Sha, Zachary Sanger, Theoden I. Netoff, Thomas Lisko, Anant Naik, Robert McGovern III, Sima Patel   +16 more
wiley   +1 more source

Mid-pregnancy allopregnanolone levels and trajectories of perinatal depressive symptoms [PDF]

Perinatal depression is a major cause of disability for individuals giving birth worldwide, with detrimental effects on short- and long-term parental and child outcomes.
Comasco, Erika, Skalkidou, Alkistis, Björvang, Richelle D., Sundström Poromaa, Inger, Walldén, Ylva, Fransson, Emma   +5 more
core   +1 more source