Results 111 to 120 of about 6,010 (206)

Disadaptive disorders in women: allopregnanolone, a sensitive steroid

Gynecological Endocrinology, 2004
Allopregnanolone, a neurosteroid acting as a potent anxiolytic agonist of the gamma-aminobutyric acid A receptor, has been shown in animal models to modify its concentrations at central and peripheral levels according to the estrous cycle. Moreover, it modulates behavioral and biochemical responses to acute and chronic stress, anxiety, depression ...
Bernardi F, Pluchino N, Begliuomini S, Lenzi E, Palumbo M, Luisi M, Genazzani AR.   +6 more
openaire   +3 more sources

Low Serum Allopregnanolone Is Associated with Symptoms of Depression in Late Pregnancy [PDF]

, 2014
Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) is a neurosteroid which has inhibitory function through interaction with the GABAA receptor. This progesterone metabolite has strong sedative and anxiolytic properties, and low endogenous levels have been ...
Sundström-Poromaa, Inger,, Sundstrom-Poromaa, Inger, Akerud, Helena, Skalkidou, Alkistis, Bäckström, Torbjörn,, Hellgren, Charlotte,, Skalkidou, Alkistis,, Hellgren, Charlotte, Åkerud, Helena,   +8 more
core   +1 more source

Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models

Scientific Reports, 2017
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple tics and sensorimotor abnormalities, the severity of which is typically increased by stress.
Laura J. Mosher, Sean C. Godar, Marianela Nelson, Stephen C. Fowler, Graziano Pinna, Marco Bortolato   +5 more
doaj   +1 more source

Animal Models of PTSD: The Socially Isolated Mouse and the Biomarker Role of Allopregnanolone

Frontiers in Behavioral Neuroscience, 2019
Post-traumatic stress disorder (PTSD) is a debilitating undertreated condition that affects 8%–13% of the general population and 20%–30% of military personnel.
Graziano Pinna
doaj   +1 more source

Allopregnanolone suppresses diabetes-induced neuropathic pain and motor deficit through inhibition of GABAA receptor down-regulation in the spinal cord of diabetic rats [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s):Painful diabetic neuropathy is associated with hyperexcitability and hyperactivity of spinal cord neurons. However, its underlying pathophysiological mechanisms have not been fully clarified.
Samira Afrazi, Saeed Esmaeili-Mahani
doaj  

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Frontiers in Cellular Neuroscience
The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological ...
Keiko Takasu, Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Koichi Ogawa   +7 more
doaj   +1 more source

Differential effects of allopregnanolone and diazepam on social behavior through modulation of neural oscillation dynamics in basolateral amygdala and medial prefrontal cortex

Frontiers in Cellular Neuroscience
Effective treatments for major depressive disorder (MDD) have long been needed. One hypothesis for the mechanism of depression involves a decrease in neuroactive steroids such as allopregnanolone, an endogenous positive allosteric modulator of the γ ...
Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Keiko Takasu, Koichi Ogawa   +7 more
doaj   +1 more source

Brief but chronic increase in allopregnanolone cause accelerated AD pathology eifferently in two mouse models [PDF]

, 2013
Previously, we have shown that chronic treatment with allopregnanolone (ALLO) for three months impaired learning function in the Swe/PS1 mouse model. ALLO is a neurosteroid, produced in the CNS and a GABAA receptor agonist.
Wang, M, Nitsch, R M, Bengtsson, S K, Johansson, M, Bäckström, T   +4 more
core  

Allopregnanolone effects in women : clinical studies in relation to the menstrual cycle, premenstrual dysphoric disorder and oral contraceptive use [PDF]

, 2011
Background: Premenstrual dysphoric disorder (PMDD) affects 3–8% of women in fertile ages. Combined oral contraceptives (OCs) are widely used and some users experience adverse mood effects.
Timby, Erika
core  

Author's Response: Allopregnanolone Assays [PDF]

Journal of Clinical Endocrinology & Metabolism, 2001
openaire   +1 more source