Post-ictal circulating levels of allopregnanolone in children with partial or generalized seizures [PDF]
, 2005 Allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) is a neurosteroid with a potent modulating activity on the gamma-aminobutyric acid (GABA)(a) receptor complex. It plays a key role in the epileptogenesis of partial seizures.
GROSSO, S. +15 more
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Indian Journal of Neurosurgery, 2020 Aim Allopregnanolone (AP) is a steroid of progesterone origin and it can readily pass through the blood–brain barrier. The aim of this study was to determine the AP levels occurring after head trauma in children and adults and to compare these results to
Göker Coskun +2 more
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Allopregnanolone serum concentrations and diurnal cortisol secretion in women with premenstrual dysphoric disorder [PDF]
, 2013 Most prior studies in patients with premenstrual dysphoric disorder (PMDD) indicate a blunted hypothalamus-pituitary-adrenal axis function. However, the relationship between neuroactive progesterone metabolites, such as allopregnanolone, and hypothalamus-
Poromaa, Inger Sundstrom +11 more
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Allopregnanolone effects on food intake and weight gain [PDF]
, 2015 Background Obesity is currently one of the major causes of ill health and it is clear that overeatingis the cause of obesity. However, the actions of many endogenous factors that contribute to overeating are still not well understood.
Holmberg, Ellinor
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Progesterone and allopregnanolone in the central nervous system: Response to injury and implication for neuroprotection [PDF]
, 2014 International audienceProgesterone is a well-known steroid hormone, synthesized by ovaries and placenta in females, and by adrenal glands in both males and females.
Gonzalez Deniselle, M, C +5 more
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Tolerance and antagonism to allopregnanolone effects in the rat CNS [Elektronisk resurs] [PDF]
, 2006 Many studies have suggested a relationship between sex steroids and negative mental and mood changes in women. Allopregnanolone, a potent endogenous ligand of the GABA-A receptor and a metabolite of progesterone, is one of the most accused neuroactive ...
Johansson, Inga-Maj, +2 more
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Low serum allopregnanolone levels in girls with precocious pubarche [PDF]
, 2005 Allopregnanolone, a neuroactive steroid, increases during pubertal development and high concentrations are present in subjects with precocious puberty.
CASAROSA, E. +17 more
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Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons
Annals of Clinical and Translational Neurology, 2020 Objective Neurosteroids regulate neuronal excitability by potentiating γ‐aminobutyric acid type‐A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Suchitra Joshi +3 more
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Persistence of tolerance to the anaesthetic effect of allopregnanolone in male rats [PDF]
, 2008 Both acute and chronic tolerance can develop to allopregnanolone-a gamma-aminobutyric acid (GABA)-modulatory progesterone metabolite. Here we investigated if acute tolerance to allopregnanolone persisted for 1 or 2 days after the induction and thus could
Wahlström, Göran, +3 more
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Chronic Stress, 2018 Allopregnanolone and pregnanolone—neurosteroids synthesized from progesterone in the brain, adrenal gland, ovary and testis—have been implicated in a range of neuropsychiatric conditions including seizure disorders, post-traumatic stress disorder, major ...
Jennifer J. Liang, Ann M. Rasmusson
doaj +1 more source