Results 131 to 140 of about 4,624 (175)

The role of allopregnanolone in depression and anxiety

Progress in Neurobiology, 2014
Neuroactive steroids such as allopregnanolone do not only act as transcriptional factors in the regulation of gene expression after intracellular back-oxidation into the 5-α pregnane steroids but may also alter neuronal excitability through interactions with specific neurotransmitter receptors.
Rainer Rupprecht, Caroline Nothdurfter
exaly   +3 more sources

Allopregnanolone in Women with Premenstrual Syndrome

Hormone and Metabolic Research, 1998
5Alpha-reduced metabolites of progesterone, especially 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) are now listed to neurosteroids. Their anesthetic properties can be explained by their allosteric interaction with GABA(A) receptors. A woman's organism is provided with an abundance of progesterone during the luteal phase of the menstrual ...
Martin Hill, Marie Bicikova, Luboslav Stárka   +2 more
exaly   +3 more sources

Allopregnanolone and mood disorders

Progress in Neurobiology, 2014
Certain women experience negative mood symptoms during the menstrual cycle and progesterone addition in estrogen treatments. In women with PMDD increased negative mood symptoms related to allopregnanolone increase during the luteal phase of ovulatory menstrual cycles. In anovulatory cycles no symptom or sex steroid increase occurs.
T, Bäckström, M, Bixo, M, Johansson, S, Nyberg, L, Ossewaarde, G, Ragagnin, I, Savic, J, Strömberg, E, Timby, F, van Broekhoven, G, van Wingen   +10 more
openaire   +3 more sources

A novel radioimmunoassay of allopregnanolone

Steroids, 1995
A radioimmunoassay for determination of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) in serum or plasma has been developed and evaluated. The method employs rabbit antiserum to 3 alpha-hydroxy-5 alpha-pregnane-11,20-dione-11-O-carboxymethyloxime bovine serum-albumin conjugate and tritiated radioligand.
M, Bicíková, O, Lapcík, R, Hampl, L, Stárka, R, Knuppen, O, Haupt, L, Dibbelt   +6 more
openaire   +2 more sources

Regenerative potential of allopregnanolone

Brain Research Reviews, 2008
The neuroendocrine status of the brain has been linked to the quality of the aging process, to the risk of Alzheimer's disease and to progression of neurodegenerative pathology. Data from multiple levels of analysis ranging from in vitro cellular models to in vivo animal models to clinical investigations indicate that the decline of neurosteroids play ...
Jun Ming, Wang, Lifei, Liu, Ronald W, Irwin, Shuhua, Chen, Roberta Diaz, Brinton   +4 more
openaire   +2 more sources