Results 141 to 150 of about 4,624 (175)
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Neurosteroids: 7-aza-allopregnanolone—a poor substitute for allopregnanolone
Tetrahedron, 20077-Nor-20-oxopregn-5-en-3β-yl acetate was converted into (20R)-5β,6β-epoxy-7-nor-5β-pregnane-3β,20-diyl diacetate in three steps. Stereospecific migration of the 6α-hydride ion led to a 6-oxo derivative with a 5α-configuration. The (Z)-oxime of this ketone underwent Beckmann rearrangement to yield a lactam with the nitrogen in position 7.
Alexander Kasal +2 more
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Alcohol, allopregnanolone and aggression in mice
Psychopharmacology, 2000Aggressive behavior of certain individual animals can be greatly increased when under the influence of low doses of alcohol. One of alcohol's neurochemical actions that may be relevant to alcohol-heightened aggression (AHA) is its positive modulation of the GABA(A) receptor complex.The objective of this study was to investigate whether alcohol ...
E W, Fish +3 more
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Serum Allopregnanolone in Women With Postpartum “Blues”
Obstetrics & Gynecology, 2001To relate serum allopregnanolone and progesterone levels postpartum to maternity "blues."Forty primiparous, healthy, married women (24-39 years of age; at least 13 years of education) who delivered healthy neonates in the Department of Obstetrics at the University of Pavia entered the present study. Blood samples were drawn at 8:30 AM on postpartum day
NAPPI, R. E. +5 more
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Allopregnanolone impairs episodic memory in healthy women
Psychopharmacology, 2008Allopregnanolone is an endogenous neuroactive steroid that, through its binding to the gamma-aminobutyric acid (GABA) A receptor, has GABA-active properties. Animal studies indicate that allopregnanolone administration results in diminished learning and memory impairment.
Torbjörn C. Bäckström +2 more
exaly +3 more sources
Flumazenil blocks the anxiolytic action of allopregnanolone
European Journal of Pharmacology, 1995In the burying behaviour test allopregnanolone (0.5 mg/rat) reduced the cumulative time of burying, interpreted as a reduction in anxiety. The selective benzodiazepine antagonist, flumazenil (5 and 10 mg/kg), did not affect the burying behaviour when administered alone but effectively prevented the reduction produced by allopregnanolone.
A, Fernández-Guasti, O, Picazo
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Anticonvulsant action of allopregnanolone in immature rats
Epilepsy Research, 2006Anticonvulsant activity of allopregnanolone, a neurosteroid allosterically modulating GABA(A) receptor was tested in a model of motor seizures elicited by pentetrazol in immature rats. Rats 7, 12, 18, 25 or 90 days old were pretreated with allopregnanolone in doses from 5 to 40 mg/kg i.p.
P, Mares +3 more
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Reinforcing effects of the neurosteroid allopregnanolone in rats
Pharmacology Biochemistry and Behavior, 2002The GABA(A) receptor positive modulator allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) is a potent neurosteroid with behavioral and biochemical characteristics similar to ethanol, barbiturates, and benzodiazepines. This suggests that neurosteroids may provide an alternative class of sedative/hypnotic, anticonvulsant, and anxiolytic ...
Rachna S, Sinnott +2 more
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Allopregnanolone Affects Sleep in a Benzodiazepine-Like Fashion
The Journal of Pharmacology and Experimental Therapeutics, 1997Recent research in rats and humans has shown that exogenous progesterone evokes a sleep profile similar to that induced by agonistic modulators of gamma-aminobutyric acid(A) receptors, such as benzodiazepines. This finding suggests the involvement of the neuroactive metabolite of progesterone, allopregnanolone.
Lancel M. +6 more
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Olanzapine increases allopregnanolone in the rat cerebral cortex
Biological Psychiatry, 2000The neurosteroid allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) has anxiolytic and anticonvulsant properties, potentiating GABA(A) receptor chloride channel function with 20-fold higher potency than benzodiazepines. Behavioral studies demonstrate that olanzapine has anxiolyticlike properties in animals, but the mechanism responsible for these ...
John Gilmore +2 more
exaly +3 more sources
Allopregnanolone and pregnanolone are produced by the human corpus luteum
Molecular and Cellular Endocrinology, 2005Using a dispersed human luteal cell culture model, progesterone, allopregnanolone and pregnanolone release following treatment by incremental doses of human chorionic gonadotrophin (hCG) were evaluated. Corpus luteum tissues, obtained from 48 healthy women scheduled for benign surgery, were grouped according to luteal age and tissue concentration of ...
Ulrika, Ottander +5 more
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