Results 151 to 160 of about 4,624 (175)
Some of the next articles are maybe not open access.
Aggressive behavior as a reinforcer in mice: activation by allopregnanolone
Psychopharmacology, 2002The neurobiological mechanisms that underlie the motivation to engage in an aggressive confrontation remain to be investigated.The objective was to develop a method to differentiate pharmacologically the performance elements of aggressive behavior from behaviors that precede an aggressive encounter.Male CFW mice were housed as "residents" and trained ...
Eric W, Fish +2 more
openaire +2 more sources
Multifunctional aspects of allopregnanolone in stress and related disorders
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2014Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) is a major cholesterol-derived neurosteroid in the central nervous system and is synthesized from progesterone by steroidogenic enzymes, 5α-reductase (the rate-limiting enzyme) and 3α-hydroxysteroid dehydrogenase.
Anjana, Bali, Amteshwar Singh, Jaggi
openaire +2 more sources
Allopregnanolone inhibits learning in the Morris water maze
Brain Research, 2002The progesterone metabolite allopregnanolone (3alpha-OH-5alpha-pregnane-20-one) inhibits neural functions, enhancing the GABA induced GABA(A) receptor activation. This effect is benzodiazepine like and benzodiazepines are known to impair memory. Acute effects of allopregnanolone on the hippocampus dependent spatial learning in the Morris water maze ...
Inga Maj, Johansson +4 more
openaire +2 more sources
Selective Effect of Allopregnanolone on Corticoliberin-Induced Anxiety
Bulletin of Experimental Biology and Medicine, 2014We studied the effect of allopregnanolone on stress-induced anxiety caused by intranasal administration of corticoliberin to male Wistar rats. Active and passive rats were selected by their T-maze behavior and then were tested in elevated plus maze for initial anxiety level. Basing on test results, the animals were divided into following groups: active
O G, Semenova, V V, Rakitskaya
openaire +2 more sources
Therapeutic implications of allopregnanolone in Alzheimer’s related depression
Behavioural Brain ResearchAlzheimer's disease (AD) and depression share common neuropathological mechanisms, with neuroinflammation, mitochondrial dysfunction, and impaired neurosteroid signalling contributing to both conditions. Allopregnanolone (ALLO), a potent neurosteroid, plays a crucial role in modulating mood, cognition, and neuroprotection via its interaction with GABA ...
Balaji, Tidke +6 more
openaire +2 more sources
ALCOHOL AND ALLOPREGNANOLONE LEVELS.
Alcoholism: Clinical & Experimental Research, 2004S Nyberg +5 more
openaire +1 more source
The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause
Psychoneuroendocrinology, 2020Graziano Pinna +2 more
exaly