Results 71 to 80 of about 4,624 (175)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, Volume 13, Issue 41, 22 July 2026.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

The Role of Allopregnanolone in Pregnancy in Predicting Postpartum Anxiety Symptoms

Frontiers in Psychology, 2019
Postpartum depression is a serious illness affecting up to 15% of women worldwide after childbirth, and our understanding of its biology is limited. Postpartum anxiety is perhaps more prevalent and less understood.
Lauren M. Osborne, Lauren M. Osborne, Joshua F. Betz, Gayane Yenokyan, Lindsay R. Standeven, Jennifer L. Payne, Jennifer L. Payne   +6 more
doaj   +1 more source

Effects of Micronized Progesterone in Menopausal Hormone Replacement Therapy on Sleep

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 7, July 2026.
ABSTRACT Aim In Japan, only synthetic progestins were available for menopausal hormone therapy until 2021. Since then, micronized progesterone has become available. Micronized progesterone binds to gamma‐aminobutyric acid type A receptors and exerts sedative and hypnotic effects.
Asuka Hirose, Masakazu Terauchi, Momo Hirata, Kazuko Matsuoka, Kenji Umayahara, Masaru Sakamoto, Naoyuki Miyasaka   +6 more
wiley   +1 more source

Anti‐apoptotic effects of allopregnanolone on P19 neurons

European Journal of Neuroscience, 2006
AbstractProgesterone and its metabolites are potent allosteric modulators of GABAAreceptor function, through a direct, non‐genomic interaction with specific receptor subtypes. In addition, fluctuations in the concentration of progesterone, and allopregnanolone in particular, have been shown to modulate GABAAreceptor gene expression and activity.
Xilouri, M., Papazafiri, P.
openaire   +3 more sources

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Neurobiology of Stress, 2019
The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials of a related neuroactive steroid, SGE-217, for men and women with major depressive disorder offer the ...
Charles F. Zorumski, Steven M. Paul, Douglas F. Covey, Steven Mennerick   +3 more
doaj   +1 more source

Molecular Mechanisms and Probe‐Dependent Effects of Clinically Relevant GABAA Receptor Modulators

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Combining molecular dynamics, dynamic pharmacophores, and allosteric network analysis, we reveal that benzodiazepines and Z‐drugs stabilize GABA binding through long‐range TMD–ECD allosteric coupling, while anesthetics directly activate the channel via unique L232/I264 contacts, bypassing GABA.
Marvin Taterra, Yuan Chang‐Halabi, Marcel Bermúdez   +2 more
wiley   +1 more source

Women with epilepsy: Evidence‐based counseling across the lifespan

Epilepsia, Volume 67, Issue 6, Page 2689-2706, June 2026.
Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn, Georgia Ramantani, Dominique Flügel, Verena Gaus, Susanne Schubert‐Bast, Elisabeth Sellitto, Jennifer Bausch, Bettina Schmitz   +7 more
wiley   +1 more source

Antioxidant and Anti-Apoptotic Properties of Allopregnanolone in Protecting Dopaminergic Neurons from 6-OHDA-Induced Injury [PDF]

Veterinary and Comparative Biomedical Research
Dopaminergic neurodegeneration is associated with oxidative stress, mitochondrial dysfunction, neuroinflammation, and cell death. Allopregnanolone, a multifunctional neurosteroid, is involved in various biological processes within the body.
Hossein Khodadadi, Hossein Jonaidi, Saeed Esmaeili-Mahani, Mehran Pourmashayekhi, Parsa Jonaidi   +4 more
doaj   +1 more source

Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons

Annals of Clinical and Translational Neurology, 2020
Objective Neurosteroids regulate neuronal excitability by potentiating γ‐aminobutyric acid type‐A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Suchitra Joshi, William H. Roden, Jaideep Kapur, Laura A. Jansen   +3 more
doaj   +1 more source

Allopregnanolone levels and depressive symptoms during pregnancy in relation to single nucleotide polymorphisms in the allopregnanolone synthesis pathway

Hormones and Behavior, 2017
Allopregnanolone, a neurosteroid whose levels rise throughout gestation, putatively stabilizes antenatal mood. The present study aimed to investigate associations of plasma allopregnanolone to antenatal depressive symptoms, as well as to genetic and obstetric factors.
Charlotte Hellgren, Erika Comasco, Alkistis Skalkidou, Inger Sundström-Poromaa   +3 more
openaire   +4 more sources