Results 71 to 80 of about 6,010 (206)
Response to Durability of zuranolone in postpartum depression versus major depressive disorder
Psychiatry and Clinical Neurosciences, Volume 80, Issue 7, Page 631-632, July 2026.This article relates to Response to Durability of zuranolone in postpartum depression versus major depressive disorder.
Masaki Kato +8 more
wiley +1 more source
Tolerance and antagonism to allopregnanolone effects in the rat CNS [PDF]
, 2006 Many studies have suggested a relationship between sex steroids and negative mental and mood changes in women. Allopregnanolone, a potent endogenous ligand of the GABA-A receptor and a metabolite of progesterone, is one of the most accused neuroactive ...
Turkmen, Sahruh
core
Pediatric super‐refractory status epilepticus treated with allopregnanolone [PDF]
, 2014 Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic γ-aminobutyric acid (GABA)A receptors, and withdrawal of ...
Craig M. Smith +17 more
core +1 more source
Divergent Transcriptomic Effects of Allopregnanolone in Postpartum Depression
Genes, 2023 Brexanolone, a formulation of the neurosteroid allopregnanolone (ALLO), is approved for treating postpartum depression (PPD) and is being investigated for therapeutic efficacy across numerous neuropsychiatric disorders. Given ALLO’s beneficial effects on mood in women with PPD compared to healthy control women, we sought to characterize and compare the
Sarah A. Rudzinskas +6 more
openaire +2 more sources
Nature Communications, 2022 Early-life adversity (ELA) increases the likelihood of neuropsychiatric diagnoses, which are more prevalent in women than men. Since changes in reproductive hormone levels can also increase the probability of anxiety disorders in women, we examined the ...
Blake J. Laham +6 more
doaj +1 more source
Molecular Mechanisms and Probe‐Dependent Effects of Clinically Relevant GABAA Receptor Modulators
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Combining molecular dynamics, dynamic pharmacophores, and allosteric network analysis, we reveal that benzodiazepines and Z‐drugs stabilize GABA binding through long‐range TMD–ECD allosteric coupling, while anesthetics directly activate the channel via unique L232/I264 contacts, bypassing GABA.
Marvin Taterra +2 more
wiley +1 more source
BMC Anesthesiology, 2022 Background Alfaxalone is a fast acting intravenous anaesthetic with high therapeutic index. It is an analogue of the naturally-occurring neurosteroid allopregnanolone responsible for maintenance of cognition and neuroprotection by activation of brain ...
Juliet M. Serrao, Colin S. Goodchild
doaj +1 more source
Women with epilepsy: Evidence‐based counseling across the lifespan
Epilepsia, Volume 67, Issue 6, Page 2689-2706, June 2026.Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn +7 more
wiley +1 more source
Pharmacokinetic parameters for allopregnanolone in both rabbit and mouse. [PDF]
, 2015 LC-MS/MS measurements of allopregnanolone in plasma (top panel) or brain (bottom panel) after a single bolus dose (mg/kg body weight) by intravenous (IV), subcutaneous (SC), or transdermal (TD) administration.Pharmacokinetic parameters for ...
Christine M. Solinsky (748884) +7 more
core +1 more source
Drug Design, Development and Therapy, 2023 Kunlin Guo,* Mingjie Mao,* Susu Zhang, Shiqin Xu, Liping Zhao, Xian Wang, Shanwu Feng Department of Anesthesiology, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province ...
Guo K +6 more
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