Results 41 to 50 of about 6,010 (206)

The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies

Biomolecules, 2022
The neuroactive steroid allopregnanolone ((3α,5α)-3-hydroxypregnan-20-one or 3α,5α-THP) plays a key role in the response to stress, by normalizing hypothalamic-pituitary-adrenal (HPA) axis function to restore homeostasis. Most studies have been conducted
Maria Giuseppina Pisu, Luca Concas, Carlotta Siddi, Mariangela Serra, Patrizia Porcu   +4 more
doaj   +1 more source

Pharmacokinetic and behavioral effects of allopregnanolone in healthy women [PDF]

, 2006
Rationale  The behavioral effects of allopregnanolone (3α-hydroxy-5α-pregnan-20-one) in women are not known. Objective  Allopregnanolone, a neuroactive steroid secreted by the mammalian ovary, exerts its anesthetic, anxiolytic, and sedative/hypnotic ...
Timby, Erika, Bäckström, Torbjörn, Porankiewicz-Asplund, Joanna, Purdy, Robert H, Poromaa, Inger Sundström, Balgård, Matts, Nyberg, Sigrid, Sundström Poromaa, Inger,, Andersson, Agneta, Zhu, Di, Spigset, Olav   +10 more
core   +1 more source

Mifepristone blocks the anxiolytic- and antidepressant-like effects of allopregnanolone in male rats [PDF]

, 2022
Allopregnanolone (3α, 5α-tetrahydroprogesterone) is an inhibitory neurosteroid synthesized from progesterone via 5α-reductase activity in the brain and has anxiolytic, antidepressant, sedative, anticonvulsant, and analgesic activity.
Divya Choudhary (8119514), R. B. Sasibhushana (14232613), B. S. Shankaranarayana Rao (14232616), B. N. Srikumar (14232619)   +3 more
core   +1 more source

Progesterone Exerts a Neuromodulatory Effect on Turning Behavior of Hemiparkinsonian Male Rats: Expression of 3α-Hydroxysteroid Oxidoreductase and Allopregnanolone as Suggestive of GABAA Receptors Involvement

Parkinson's Disease, 2015
There is a growing amount of evidence for a neuroprotective role of progesterone and its neuroactive metabolite, allopregnanolone, in animal models of neurodegenerative diseases.
Roberto Yunes, Sebastián Casas, Eliana Gaglio, Ricardo Cabrera   +3 more
doaj   +1 more source

Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age

Frontiers in Psychology, 2019
Allopregnanolone is a metabolite of the sex hormone progesterone, with suggested relevance for female mood disorders. While allopregnanolone and serotonin are known to influence psychological well-being, the molecular and psychological specifics of their
Inger Sundström Poromaa, Erika Comasco, Torbjörn Bäckström, Marie Bixo, Peter Jensen, Vibe G. Frokjaer, Vibe G. Frokjaer   +6 more
doaj   +1 more source

Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone

Molecular Pain, 2022
Orofacial pain disorders are predominately experienced by women. Progesterone, a major ovarian hormone, is neuroprotective and antinociceptive. We recently reported that progesterone attenuates estrogen-exacerbated orofacial pain behaviors, yet it ...
Rebecca S Hornung, Namrata GR Raut, Daisy J Cantu, Lauren M Lockhart, Dayna L Averitt   +4 more
doaj   +1 more source

Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well‐established preclinical safety efficacy make it a viable
Gerson D. Hernandez, Christine M. Solinsky, Wendy J. Mack, Naoko Kono, Kathleen E. Rodgers, Chun‐Yi Wu, Ana R. Mollo, Claudia M. Lopez, Sonia Pawluczyk, Gerhard Bauer, Dawn Matthews, Yonggang Shi, Meng Law, Michael A. Rogawski, Lon S. Schneider, Roberta D. Brinton   +15 more
doaj   +1 more source

Prenatal resident-intruder stress decreases levels of allopregnanolone in the cortex, hypothalamus, and midbrain of males, and increases levels in the hippocampus and cerebellum of female, juvenile rat offspring

Neurobiology of Stress, 2020
Prenatal stress (PNS) can influence behaviors associated with cognition, reward and emotional regulation, which are controlled by brain areas such as the cortex, hippocampus, hypothalamus, midbrain and cerebellum.
Jennifer K. Torgersen, Rose Petitti, Sedric Tello, Vincent F. Lembo, Cheryl A. Frye   +4 more
doaj   +1 more source

Allopregnanolone modulation of HPA axis function in the adult rat [PDF]

, 2014
Rationale GABAergic neuronal circuits regulate neuroendo- crine stress response, and the most potent positive endogenous modulator of GABAA receptor function is allopregnanolone.
SERRA, MARIANGELA, Pisu MG, BIGGIO, FRANCESCA, Biggio G   +3 more
core   +1 more source

Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression

Frontiers in Endocrinology, 2011
The pharmacological action of SSRI antidepressants may include a normalization of the decreased brain levels of neurosteroids such as that of the progesterone metabolite allopregnanolone and that of the brain-derived neurotrophic factor (BDNF), which are
Mauricio Schüler Nin, Mauricio Schüler Nin, Luis eMartinez, Fabio ePibiri, Marianela eNelson, Graziano ePinna   +5 more
doaj   +1 more source