Results 21 to 30 of about 6,010 (206)
The fetal brain: role of progesterone and allopregnanolone [PDF]
Hormone Molecular Biology and Clinical Investigation, 2019 Progesterone and allopregnanolone have crucial and different roles in brain development, function and recovery after injury. Pregnancy is characterized by an increased synthesis of progesterone and its neuro-active metabolites by the placenta, maternal ...
Pluchino, Nicola +2 more
core +3 more sources
Allopregnanolone effects on inhibition in hippocampal parvalbumin interneurons [PDF]
eneuro, 2023 Allopregnanolone (AlloP) is a neurosteroid that potentiates ionotropic GABAergic ...
Zorumski, Charles F +4 more
core +5 more sources
Allopregnanolone affects sleep in a benzodiazepine-like fashion [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 1997 Recent research in rats and humans has shown that exogenous progesterone evokes a sleep profile similar to that induced by agonistic modulators of gamma-aminobutyric acid(A) receptors, such as benzodiazepines. This finding suggests the involvement of the
Holsboer F. +7 more
core +5 more sources
Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease. [PDF]
PLoS ONE, 2015 To develop allopregnanolone as a therapeutic for Alzheimer's disease, we investigated multiple formulations and routes of administration in translationally relevant animal models of both sexes.
Ronald W Irwin +7 more
doaj +2 more sources
Allopregnanolone in Postpartum Depression
Frontiers in Global Women's Health, 2022 Postpartum depression (PPD) is a debilitating psychiatric disorder characterized by a high worldwide prevalence and serious long-term negative outcomes for both mothers and children. The lack of a specific treatment and overreliance on pharmacotherapy with limited efficacy and delayed treatment response has constituted a complication in the management ...
Graziano Pinna +3 more
openaire +3 more sources
Journal of Clinical Endocrinology & Metabolism, 2001 Author's Response: Allopregnanolone ...
Pearson Murphy, Beverley E. +1 more
openaire +2 more sources
Allopregnanolone: An overview on its synthesis and effects [PDF]
Journal of Neuroendocrinology, 2021 Abstract Allopregnanolone, a 3α,5α‐progesterone metabolite, acts as a potent allosteric modulator of the γ‐aminobutyric acid type A receptor. In the present review, the synthesis of this neuroactive steroid occurring in the nervous system is discussed with respect to physiological and pathological conditions.
Silvia Diviccaro +4 more
openaire +2 more sources
Allopregnanolone and reproductive psychiatry: an overview [PDF]
International Review of Psychiatry, 2019 Psychiatric symptoms that coincide with reproductive transitions are related to changes in sex steroids, but studies show that this relationship is governed by individual women's vulnerability to change rather than by differences in level. There is growing interest in the role of allopregnanolone (ALLO), a 3-α reduced metabolite of progesterone and a ...
Katherine, McEvoy, Lauren M, Osborne
openaire +2 more sources
Allopregnanolone-analogue photolabeling reagents. [PDF]
, 2019 (A) The structure of allopregnanolone, KK123, KK200, and KK202. (B). Allopregnanolone (1 μM) and the photolabeling reagents (10 μM) potentiate GABA-elicited currents of α1β3-GABAA receptors; potentiation is blocked by mutation of α1Q242Lβ3, indicating ...
Ming-Xing Qian (6433922) +12 more
core +1 more source
receptor sensitivity to allopregnanolone [PDF]
, 2015 ObjectiveSeveral studies have reported that -aminobutyric acid (GABA) ergic circuits are involved in the pathophysiology of polycystic ovary syndrome (PCOS).
Ida Gideonsson +13 more
core +1 more source