Results 21 to 30 of about 4,624 (175)

Neuroregenerative Mechanisms of Allopregnanolone in Alzheimer’s Disease [PDF]

Frontiers in Endocrinology, 2012
The proliferative pool and regenerative potential of neural stem cells diminishes with age, a phenomenon that may be exacerbated in prodromal and mild Alzheimer's disease (AD) brains. In parallel, the neuroactive progesterone metabolite, allopregnanolone (APα), along with a host of other factors, is decreased in the AD brain.
Irwin, Ronald W., Wang, Jun Ming, Chen, Shuhua, Brinton, Roberta Diaz   +3 more
openaire   +3 more sources

Novel receptor targets for production and action of allopregnanolone in the central nervous system: a focus on pregnane xenobiotic receptor

Frontiers in Cellular Neuroscience, 2014
Neurosteroids are cholesterol-based hormones that can be produced in the brain, independent of secretion from peripheral endocrine glands, such as the gonads and adrenals.
Cheryl A Frye, Carolyn J Koonce, Alicia A Walf   +2 more
doaj   +1 more source

Allopregnanolone and neuroinflammation: a focus on multiple sclerosis [PDF]

Frontiers in Cellular Neuroscience, 2014
The progesterone derivative allopregnanolone (ALLO) is one of the most widely studied compounds among neurosteroids. Through interactions with GABA-A receptors expressed by neurons and glial cells, ALLO has been shown to affect diverse aspects of neural cell physiology, including cell proliferation and survival, migration, and gene expression.
Noorbakhsh, Farshid, Baker, Glen B., Power, Christopher   +2 more
openaire   +3 more sources

Allopregnanolone and neurogenesis in the nigrostriatal tract [PDF]

Frontiers in Cellular Neuroscience, 2014
Reinstalling the neurobiological circuits to effectively change the debilitating course of neurodegenerative diseases is of utmost importance. This reinstallation requires generation of new cells which are able to differentiate into specific types of neurons and modification of the local environment suitable for integration of these new neurons into ...
openaire   +3 more sources

Allopregnanolone and Pregnanolone Are Reduced in the Hippocampus of Epileptic Rats, but Only Allopregnanolone Correlates with Seizure Frequency

Neuroendocrinology, 2020
<b><i>Background:</i></b> Neurosteroids modulate epileptic activity by interacting with the γ-aminobutyric acid type A receptor, but their brain levels are still undetermined. <b><i>Objectives:</i></b> We aimed to establish neurosteroid levels in the neocortex and hippocampus by liquid chromatography/mass
Lucchi Chiara, Costa Anna Maria, Rustichelli Cecilia, Biagini Giuseppe   +3 more
openaire   +3 more sources

Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

Biology of Sex Differences, 2022
Highlights Progesterone has sex-dependent effects on smoking measures in individuals with Tobacco Use Disorder. Higher conversion of progesterone to allopregnanolone (as indicated by the allopregnanolone:progesterone ratio) was associated with lower ...
Andrew M. Novick, Korrina A. Duffy, Rachel L. Johnson, Mary D. Sammel, Wen Cao, Andrew A. Strasser, Mehmet Sofuoglu, Alexandra Kuzma, James Loughead, A. Leslie Morrow, C. Neill Epperson   +10 more
doaj   +1 more source

Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.

PLoS ONE, 2015
To develop allopregnanolone as a therapeutic for Alzheimer's disease, we investigated multiple formulations and routes of administration in translationally relevant animal models of both sexes.
Ronald W Irwin, Christine M Solinsky, Carlos M Loya, Francesco G Salituro, Kathleen E Rodgers, Gerhard Bauer, Michael A Rogawski, Roberta Diaz Brinton   +7 more
doaj   +1 more source

GABAA/Benzodiazepine Receptor Complex in the Dorsal Hippocampus Mediates the Effects of Chrysin on Anxiety-Like Behaviour in Female Rats

Frontiers in Behavioral Neuroscience, 2022
Systemic injections of the flavonoid chrysin (5,7-dihydroxyflavone) exert anxiolytic-like effects in ovariectomised and cycling female rats through actions on gamma-aminobutyric acid-A (GABAA) receptors; however, it is unknown if chrysin directly acts on
Juan Francisco Rodríguez-Landa, Juan Francisco Rodríguez-Landa, Fabiola Hernández-López, Lucía Martínez-Mota, Damiana Scuteri, Damiana Scuteri, Blandina Bernal-Morales, Blandina Bernal-Morales, Eduardo Rivadeneyra-Domínguez   +8 more
doaj   +1 more source

The neurosteroid allopregnanolone sulfate inhibits Nav1.3 α subunit-containing voltage-gated sodium channels, expressed in Xenopus oocytes

Journal of Pharmacological Sciences, 2018
The neurosteroid allopregnanolone has potent analgesic effects, and its potential use for neuropathic pain is supported by recent reports. However, the analgesic mechanisms are obscure.
Takafumi Horishita, Nobuyuki Yanagihara, Susumu Ueno, Dan Okura, Reiko Horishita, Tomoko Minami, Yuichi Ogata, Yuka Sudo, Yasuhito Uezono, Takashi Kawasaki   +9 more
doaj   +1 more source

Structural insights into opposing actions of neurosteroids on GABAA receptors

Nature Communications, 2023
γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids.
Dagimhiwat H. Legesse, Chen Fan, Jinfeng Teng, Yuxuan Zhuang, Rebecca J. Howard, Colleen M. Noviello, Erik Lindahl, Ryan E. Hibbs   +7 more
doaj   +1 more source