Results 11 to 20 of about 6,010 (206)

Biosynthesis and biological action of pineal allopregnanolone [PDF]

Frontiers in Cellular Neuroscience, 2014
The pineal gland transduces photoperiodic changes to the neuroendocrine system by rhythmic secretion of melatonin. We recently provided new evidence that the pineal gland is a major neurosteroidogenic organ and actively produces a variety of ...
Kazuyoshi eTsutsui, Shogo eHaraguchi
doaj   +5 more sources

Allopregnanolone and mood disorders [PDF]

Progress in Neurobiology, 2014
Certain women experience negative mood symptoms during the menstrual cycle and progesterone addition in estrogen treatments. In women with PMDD increased negative mood symptoms related to allopregnanolone increase during the luteal phase of ovulatory ...
Strömberg, J., Timby, E., Savic, I., Ossewaarde, L, Timby, E, Nyberg, Sigrid,, Strömberg, J, van Broekhoven, F., Nyberg, S., van Broekhoven, F, van Wingen, G., Johansson, Maja,, Bixo, M., van, Broekhoven F, Ragagnin, Gianna,, Bäckström, Torbjörn,, Nyberg, S, Bäckström, T., Johansson, M, Bixo, M, Johansson, M., Ossewaarde, L., Ragagnin, G., van Wingen, G, Bixo, Marie,, Savic, I, Backstrom, T, Timby, Erika,, Ragagnin, G   +28 more
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Allopregnanolone: state of the art. [PDF]

Progress in Neurobiology, 2014
Allopregnanolone, a neuroactive steroid derived from progesterone, is synthesized within the nervous tissue, by means of specific enzymes. Contrary to progesterone and its first metabolite dihydroprogesterone, allopregnanolone is able to interact with ...
Panzica, Giancarlo, G. C. Panzica, R.C. Melcangi   +2 more
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Allopregnanolone concentrations and premestrual syndrome [PDF]

European Journal of Endocrinology, 2000
OBJECTIVE: To evaluate basal allopregnanolone and progesterone in both phases of the menstrual cycle in women suffering from premenstrual syndrome (PMS) and their response to a GnRH test.
TONETTI, A., MONTELEONE, P., GENAZZANI, A. R., Luisi, M, GENAZZANI, A. D., GENAZZANI, Alessandro, PETRAGLIA, F., Luisi, S, BERNARDI, F., LUISI, S., Petraglia, F, Tonetti, A, Monteleone, P, LUISI, M., Bernardi, F   +14 more
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Serum allopregnanolone in women with postpartum “blues” [PDF]

Obstetrics & Gynecology, 2001
To relate serum allopregnanolone and progesterone levels postpartum to maternity "blues." Objective: To relate serum allopregnanolone and progesterone levels postpartum to maternity "blues." Methods: Forty primiparous, healthy, married women (24-39 ...
NAPPI, R. E., LUISI, S., GENAZZANI, A. R., FARINA, C., POLATTI, F., PETRAGLIA, F.   +5 more
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Allopregnanolone levels and depressive symptoms during pregnancy in relation to single nucleotide polymorphisms in the allopregnanolone synthesis pathway [PDF]

Hormones and Behavior, 2017
Allopregnanolone, a neurosteroid whose levels rise throughout gestation, putatively stabilizes antenatal mood. The present study aimed to investigate associations of plasma allopregnanolone to antenatal depressive symptoms, as well as to genetic and ...
Alkistis Skalkidou, Comasco, Erika, Inger Sundström-Poromaa, Skalkidou, Alkistis, Sundström Poromaa, Inger, Erika Comasco, Hellgren, Charlotte,, Comasco, Erika,, Skalkidou, Alkistis,, Sundström Poromaa, Inger,, Hellgren, Charlotte, Charlotte Hellgren   +11 more
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Tolerance to allopregnanolone with focus on the GABA-A receptor [PDF]

British Journal of Pharmacology, 2010
Many studies have suggested a relationship between stress, sex steroids, and negative mental and mood changes in humans. The progesterone metabolite allopregnanolone is a potent endogenous ligand of the γ-amino butyric acid -A (GABA-A) receptor, and the ...
Wahlström, Göran,, Bäckström, Torbjörn,, Johansson, Inga-Maj,, Sahruh Turkmen, Lotta Andreen, Torbjorn Backstrom, Goran Wahlstrom, Turkmen, Sahruh,, Inga-Maj Johansson, Andréen, Lotta,   +9 more
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Allopregnanolone in the brain: protecting pregnancy and birth outcomes [PDF]

Progress in Neurobiology, 2014
A successful pregnancy requires multiple adaptations in the mother's brain that serve to optimise fetal growth and development, protect the fetus from adverse prenatal programming and prevent premature delivery of the young.
John A. Russell, Hirst, Jonathan J., Paula J. Brunton, Brunton, Paula, Russell, John, Jonathan J. Hirst   +5 more
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Allopregnanolone inhibits learning in the Morris water maze [PDF]

Brain Research, 2002
The progesterone metabolite allopregnanolone (3alpha-OH-5alpha-pregnane-20-one) inhibits neural functions, enhancing the GABA induced GABA(A) receptor activation. This effect is benzodiazepine like and benzodiazepines are known to impair memory.
Olsson, T, Bäckström, T,, Lindblad, Charlotte,, Birzniece, Vita,, Johansson, I-M,   +4 more
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Allopregnanolone alters follicular and luteal dynamics during the estrous cycle [PDF]

Reproductive Biology and Endocrinology, 2018
Background Allopregnanolone is a neurosteroid synthesized in the central nervous system independently of steroidogenic glands; it influences sexual behavior and anxiety.
Joana Antonela Asensio, Antonella Rosario Ramona Cáceres, Laura Tatiana Pelegrina, María de los Ángeles Sanhueza, Leopoldina Scotti, Fernanda Parborell, Myriam Raquel Laconi   +6 more
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