Results 11 to 20 of about 4,624 (175)
Biosynthesis and biological action of pineal allopregnanolone [PDF]
Frontiers in Cellular Neuroscience, 2014 The pineal gland transduces photoperiodic changes to the neuroendocrine system by rhythmic secretion of melatonin. We recently provided new evidence that the pineal gland is a major neurosteroidogenic organ and actively produces a variety of ...
Kazuyoshi eTsutsui, Shogo eHaraguchi
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Allopregnanolone in postpartum depression: Role in pathophysiology and treatment
Neurobiology of Stress, 2020 Postpartum depression (PPD) is a unique subtype of major depressive disorder and a substantial contributor to maternal morbidity and mortality. In addition to affecting the mother, PPD can have short- and long-term consequences for the infant and partner.
Samantha Meltzer-Brody, Stephen J. Kanes
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Brexanolone, a First-In-Class Neurosteroid Medication: Mechanism of Action, Clinical, and Translational Science. [PDF]
Clin Transl SciABSTRACT Given the increasing prevalence of postpartum depression (PPD) and the stigma associated with this condition, it is essential to address this significant health concern. Brexanolone is an FDA‐approved treatment for PPD that works by positive‐allosteric modulation of type A γ‐aminobutyric acid (GABAA) receptors.
Gayanova L +4 more
europepmc +2 more sources
Allopregnanolone in Postpartum Depression
Frontiers in Global Women's Health, 2022 Postpartum depression (PPD) is a debilitating psychiatric disorder characterized by a high worldwide prevalence and serious long-term negative outcomes for both mothers and children. The lack of a specific treatment and overreliance on pharmacotherapy with limited efficacy and delayed treatment response has constituted a complication in the management ...
Graziano Pinna +3 more
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Journal of Clinical Endocrinology & Metabolism, 2001 Author's Response: Allopregnanolone ...
Pearson Murphy, Beverley E. +1 more
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Response to Durability of zuranolone in postpartum depression versus major depressive disorder. [PDF]
Psychiatry Clin NeurosciThis article relates to Response to Durability of zuranolone in postpartum depression versus major depressive disorder.
Kato M +8 more
europepmc +2 more sources
Allopregnanolone: An overview on its synthesis and effects [PDF]
Journal of Neuroendocrinology, 2021 Abstract Allopregnanolone, a 3α,5α‐progesterone metabolite, acts as a potent allosteric modulator of the γ‐aminobutyric acid type A receptor. In the present review, the synthesis of this neuroactive steroid occurring in the nervous system is discussed with respect to physiological and pathological conditions.
Silvia Diviccaro +4 more
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Allopregnanolone concentrations and premenstrual syndrome [PDF]
European Journal of Endocrinology, 2000 OBJECTIVE: To evaluate basal allopregnanolone and progesterone in both phases of the menstrual cycle in women suffering from premenstrual syndrome (PMS) and their response to a GnRH test. DESIGN: We selected 56 women (28 patients with PMS and 28 controls) aged between 18 and 32 years. Blood samples were drawn in both follicular and phases. Twenty-eight
Monteleone, P +7 more
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Allopregnanolone and reproductive psychiatry: an overview [PDF]
International Review of Psychiatry, 2019 Psychiatric symptoms that coincide with reproductive transitions are related to changes in sex steroids, but studies show that this relationship is governed by individual women's vulnerability to change rather than by differences in level. There is growing interest in the role of allopregnanolone (ALLO), a 3-α reduced metabolite of progesterone and a ...
Katherine, McEvoy, Lauren M, Osborne
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Allopregnanolone: State of the art
Progress in Neurobiology, 2014 Allopregnanolone, a neuroactive steroid derived from progesterone, is synthesized within the nervous tissue, by means of specific enzymes. Contrary to progesterone and its first metabolite dihydroprogesterone, allopregnanolone is able to interact with GABA-A receptor and not with the classical progesterone receptor.
R.C. Melcangi, G. C. Panzica
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