Results 71 to 80 of about 12,871 (217)
Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone
Frontiers in Cellular Neuroscience, 2014 A growing number of studies indicate that 3-alpha reduced neurosteroids are remarkable analgesics in various pain states. This is the case for allopregnanolone (AP), one of the most potent endogenous positive allosteric modulators of GABAA receptor ...
Pierrick ePoisbeau +6 more
doaj +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
Epilepsia, 2019 Sex differences are evident in the antiseizure activity of neurosteroids; however, the potential mechanisms remain unclear. In this study, we sought to determine whether differences in target extrasynaptic δ‐subunit γ‐aminobutyric acid type A (GABA‐A ...
D. Reddy +3 more
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray +16 more
wiley +1 more source
The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells
Frontiers in Endocrinology, 2011 Since the first observations on the existence of neurosteroids in the 1980’s, our understanding of the importance of these endogenous steroids in the control of the central and peripheral nervous system has increased progressively.
Alessandro eFaroni +2 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.Epileptogenic stress upregulates HSPA1A, impairs AP2B1 O‐GlcNAcylation and stability, and promotes GluA2 loss‐associated CP‐AMPAR formation and Ca2+ overload. B9 attenuates epileptogenesis by targeting the HSPA1A–AP2B1 axis, restoring AP2B1 O‐GlcNAcylation and stability, preserving GluA2‐associated AMPAR regulation, and reducing pathological Ca2 ...
Zixiao Tan +7 more
wiley +1 more source
Epilepsy surgery through a reproductive lifespan lens
Epilepsia, EarlyView.
Aisha A. Abdulrazaq +2 more
wiley +1 more source
Addiction Biology, Volume 31, Issue 10, October 2026.Alcohol use disorder (AUD) is a major global health burden. The study analysed female sex hormones on drinking outcomes in a multicentre longitudinal setting involving daily EMA in 70 women and 256 men over 12 months. Women reported fewer craving and loss of control during the mid‐ and late luteal cycle phases.
Sabine Hoffmann +30 more
wiley +1 more source
Neurosteroids and Neuropathic Pain Management: basic evidence and therapeutic perspectives.
Frontiers in neuroendocrinology (Print), 2019 Complex mechanisms involved in neuropathic pain that represents a major health concern make its management complicated. Because neurosteroids are bioactive steroids endogenously synthesized in the nervous system, including in pain pathways, they appear ...
Laurence Meyer +3 more
semanticscholar +1 more source
The Roles of EETs in Neurological Disorders
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid (ARA) via cytochrome P450 (CYP450) enzymes, are produced in nearly all human tissues and exert a wide range of beneficial effects. This review summarizes the roles and potential mechanisms of EETs in neurological disorders, with a focus on cerebrovascular diseases, epilepsy, Parkinson's ...
Rong Tang +6 more
wiley +1 more source