Results 81 to 90 of about 12,871 (217)

Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam

open access: yesJournal of Pharmacology and Experimental Therapeutics, 2019
Epilepsy is often treated with a combination of antiepileptic drugs. Although neurosteroids are potent anticonvulsants, little is known about their combination potential for the treatment of refractory epilepsy.
Shu-Hui Chuang, D. Reddy
semanticscholar   +1 more source

Dietary Intake of Animal and Plant‐Based Protein on Adiposity Measurements and Body Composition in Pre‐ and Postmenopausal Women: A Systematic Review of Randomized Clinical Trials

open access: yesThe FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Graphical summary of the effects of additional intake of animal and plant proteins on anthropometric and body composition parameters in pre‐ and postmenopausal women. The arrows indicate an increase, decrease, or no significant effect. ABSTRACT This systematic review investigated the effect of protein intake on anthropometric and body composition ...
Sthéfany Nonato Fialho   +4 more
wiley   +1 more source

Holistic management of epilepsy in adults with intellectual development disorders

open access: yesEpileptic Disorders, Volume 28, Issue 4, Page 981-1006, August 2026.
Abstract This seminar addresses the complexity of the management of epilepsy in adults with intellectual development disorders (IDD), advocating holistic and multidisciplinary care aligned with the learning objectives of the International League Against Epilepsy. Epilepsy is significantly more prevalent in people with IDD, presenting unique diagnostic,
Elena Fonseca   +10 more
wiley   +1 more source

Clinical Potential of Neurosteroids for CNS Disorders

open access: yesTIPS - Trends in Pharmacological Sciences, 2016
Summary Neurosteroids are key endogenous molecules in the brain that affect many neural functions. Here, we describe recent advances in NIH-sponsored and other clinical studies of neurosteroids for CNS disorders.
D. Reddy, William A Estes
semanticscholar   +1 more source

Pre‐anaesthetic risk assessment and management of dogs with myxomatous mitral valve disease: a spectrum of care narrative review

open access: yesJournal of Small Animal Practice, Volume 67, Issue 8, Page 663-679, August 2026.
Myxomatous mitral valve disease, an acquired valvular degeneration, is the most common cardiac disorder in dogs, affecting approximately 10% of dogs in primary care veterinary practice. Dogs with myxomatous mitral valve disease frequently require anaesthesia for routine procedures.
I. Levinzon   +3 more
wiley   +1 more source

Calcium-engaged Mechanisms of Nongenomic Action of Neurosteroids

open access: yes, 2018
Background: Neurosteroids form the unique group because of their dual mechanism of action. Classically, they bind to specific intracellular and/or nuclear receptors, and next modify genes transcription.
Zylinska, Ludmila   +3 more
core   +1 more source

7alpha-Hydroxypregnenolone, a new key regulator of locomotor activity of vertebrates: Identification, mode of action and functional significance

open access: yesFrontiers in Endocrinology, 2010
Steroids synthesized de novo by the central and peripheral nervous systems are called neurosteroids. The formation of neurosteroids from cholesterol in the brain was originally demonstrated in mammals by Baulieu and colleagues.
Kazuyoshi eTsutsui   +5 more
doaj   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

open access: yesAutism Research, Volume 19, Issue 7, July 2026.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin   +3 more
wiley   +1 more source

Neurosteroids for a successful pregnancy

open access: yesStress, 2010
Steroid hormones play a critical role in the initiation and maintenance of pregnancy. In particular, the important role that the progesterone metabolite, and neurosteroid, allopregnanolone, may play in fetal and adolescent development is becoming increasingly evident.
Cheryl A, Frye   +3 more
openaire   +2 more sources

Neurosteroids as Endogenous Modulators of Epileptic Seizures

open access: yes, 2015
Neurosteroids are a family of steroidal compounds which produce a variety of biological effects, mainly by interacting with the γ-aminobutyric acid receptor A (GABAA).
Giuseppe Biagini   +3 more
core   +1 more source

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