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Neurosteroids and Psychiatric Disorders

, 2014
Neurosteroids and Psychiatric ...
Flvio Kapczinski (15809594), Carolina Gubert (9576788), Bruna M Ascoli (13760443), Bruna Panizzutti (5469140), Giovana Bristot (8071169), Adriane R Rosa (13473766)   +5 more
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Of cilia, titin, and neurosteroids [PDF]

Journal of General Physiology, 2014
This month’s installment of Generally Physiological discusses a calcium compartment in primary cilia, how changes in titin splicing can lead to skeletal muscle myopathy, and a negative feedback loop whereby a neurosteroid protects against hyperactivation of type-1 cannabinoid (CB1) receptors.
openaire   +2 more sources

Pregnanolone-Based Prodrugs as a Strategy for Neuroprotective Drug-Like Compounds: Pregnanolone Pyroglutamate and Its Age‑dependent Anticonvulsant Effects in the 6-hz Seizure Model in Immature Rats

Drug Design, Development and Therapy
Pavel Mareš,1 Hana Chodounská,2 Ewa Szczurowska,2 Hana Kubová,1 Eva Kudova2 1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic; 2Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech ...
Mareš P, Chodounská H, Szczurowska E, Kubová H, Kudova E   +4 more
doaj  

Neurosteroid Biosynthesis and Action in the Purkinje Cell

Journal of Experimental Neuroscience, 2009
It is now clearly established that steroids can be synthesized de novo by the vertebrate brain. Such steroids are called neurosteroids. To understand neurosteroid action in the brain, data on the regio- and temporal-specific synthesis of neurosteroids ...
Kazuyoshi Tsutsui
doaj   +1 more source

Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease

Frontiers in Molecular Neuroscience, 2018
Gonadal steroid hormones are neurotrophic and neuroprotective. These effects are modulated by local metabolism of the hormones within the brain. Such control is necessary to maintain normal function, as several signaling pathways that are activated by ...
Ari Loren Mendell, Neil James MacLusky
doaj   +1 more source

Social isolation as a promising animal model of PTSD comorbid suicide: neurosteroids and cannabinoids as possible treatment options.

Progress in Neuro-psychopharmacology and Biological Psychiatry, 2019
Post-traumatic stress disorder (PTSD) is a psychiatric condition characterized by drastic alterations in mood, emotions, social abilities and cognition. Notably, one aspect of PTSD, particularly in veterans, is its comorbidity with suicide.
A. Locci, G. Pinna
semanticscholar   +1 more source

Neurosteroids in Pain Management: A New Perspective on an Old Player

Frontiers in Pharmacology, 2018
Since the discovery of the nervous system’s ability to produce steroid hormones, numerous studies have demonstrated their importance in modulating neuronal excitability.
S. Joksimovic, D. Covey, V. Jevtovic-Todorovic, S. Todorovic   +3 more
semanticscholar   +1 more source

Neurosteroids in learning and memory processes.

, 2019
International audienceThe discovery that neurosteroids could be synthesized de novo in the brain independent from the periphery and display neuronal actions led to great enthusiasm for the study of their physiological role.
Mayo, W., Vallée, M., Koob, G, Le Moal, M.   +3 more
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Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Eser, Daniela, Eser D., Baghai, Thomas C., Schule C., Romeo, Elena, Baghai T. C., Schuele, Cornelius, Rupprecht R., Rupprecht, Rainer, Eser D., Schule C., Baghai T.C., Romeo E., Rupprecht R.   +9 more
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Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids

Frontiers in Endocrinology, 2018
The brain is not only the target of steroid hormones but also is able to locally synthesize steroids de novo. Evidence of the local production of steroids in the brain has been accumulating in various vertebrates, including teleost fish, amphibia, birds,
Y. Hojo, S. Kawato
semanticscholar   +1 more source