Results 111 to 120 of about 12,871 (217)

Neurosteroids in the Pathophysiology and Treatment of Mood and Anxiety Disorders

, 2018
Neurosteroids have been implicated in the pathophysiology of mood, anxiety, and trauma-related disorders, as well as syndromes specific to women such as premenstrual syndrome, premenstrual dysphoric disorder, postpartum depression, peri- and post ...
Newport, D, Perkins, Elizabeth
core   +1 more source

Cellular and molecular mechanisms of action of neurosteroids in various parts of the central nervous system (Part 2)

Якутский медицинский журнал
Neurosteroids (or neuroactive steroids) are a class of endogenous compounds which are synthesized in nervous tissue or\and able to modulate the brain functional activity, the class also includes steroids from gonads or adrenals, which are capable of ...
D. V. Dmitrenko, S. N. Zobova, T. G. Ruksha, T. I. Prusova, A. A. Usoltseva   +4 more
doaj   +1 more source

Neurosteroids and neurological disorders

The Korean Journal of Physiology & Pharmacology
Neurosteroids play an important role as endogenous neuromodulators that are locally produced in the central nervous system and rapidly change the excitability of neurons and the activation of microglial cells and astrocytes. Here we review the mechanisms of synthesis, metabolism, and actions of neurosteroids in the central nervous system. Neurosteroids
Park, Gi Wan, Kim, Hayoung, Won, Seong Hyun, Kim, Nam Hyun, Choi, Sheu-Ran   +4 more
openaire   +2 more sources

Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning.

PLoS ONE
Pro-inflammatory changes contribute to multiple neuropsychiatric illnesses. Understanding how these changes are involved in illnesses and identifying strategies to alter inflammatory responses offer paths to potentially novel treatments.
Yukitoshi Izumi, Kazuko A O'Dell, Anil G Cashikar, Steven M Paul, Douglas F Covey, Steven J Mennerick, Charles F Zorumski   +6 more
doaj   +1 more source

Modulation of Glutamate-mediated Neuronal Cell Death by Neurosteroids [PDF]

, 2011
Traumatic brain injury (TBI) is a major cause of death and permanent disability in the United States. Approximately 1.7 million cases of TBI are reported annually.
Phelps, Benjamin J.
core  

Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life

Neuropsychiatric Disease and Treatment, 2018
Chien-Yu Chen,1 Chih-Ching Wu,2,3 Yu-Chi Huang,1 Chi-Fa Hung,1 Liang-Jen Wang4 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; 2Molecular Medicine Research Center, Chang ...
Chen CY, Wu CC, Huang YC, Hung CF, Wang LJ   +4 more
doaj  

Ethanol markedly increases "GABAergic" neurosteroids in alcohol-preferring rats

, 1999
Alcohol administration (1 g/kg, i.p.) increased the levels of the neurosteroids 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) and 3alpha,21-dihydroxy-5alpha-pregnan-20-one (allotetrahydrodeoxycorticosterone, THDOC) in the cerebral cortex and ...
TRABUCCHI, MARCO MARIO, BARBACCIA, MARIA LUISA, Colombo, G, Purdy, RH, Agabio, R, Gessa, GL, Affricano, D   +6 more
core   +1 more source

The neurosteroid paradigm in perinatal depression: From pathophysiology to precision therapeutics. [PDF]

J Neuroendocrinol
Radonjić NV, Moon KC, Deligiannidis KM.
europepmc   +1 more source

Distinct Modulation of High- and Low-Frequency Activity by Midazolam and Neurosteroids in Neocortical Slices. [PDF]

Int J Mol Sci
Bieletzki S, Gotthard C, Puig-Bosch X, Zeilhofer HU, Rudolph U, Rammes G, Antkowiak B, Drexler B.   +7 more
europepmc   +1 more source

Epilepsy and exercise: a narrative review on the crucial role of neurosteroids in modulating GABAergic neurotransmission. [PDF]

Brain Commun
Bonanni R, Sansone U, Cariati I, Gaeta A, Lissner LJ, Alfano V, Palma E, Ruffolo G, Cifelli P.   +8 more
europepmc   +1 more source