Results 131 to 140 of about 5,285 (165)
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Neurosteroids and status epilepticus
Current Opinion in Endocrine and Metabolic Research, 2022Status epilepticus (SE) is a common neurological emergency with considerable associated health-care costs, morbidity, and mortality. In about one-third of cases, SE is refractory towards first-line intravenous benzodiazepines. Allopregnanolone, a neurosteroid that positively modulates synaptic and extrasynaptic γ-aminobutyric acid type A receptors, has
Gol, Mohammad +2 more
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Neurosteroids in depression: a review
Psychopharmacology, 2003 A deregulation in concentrations of the neurosteroids (allo)pregnanolone and 3alpha,5alpha-tetrahydrodeoxycorticosterone (3alpha,5alpha-TH DOC) has been found in depressed patients. These levels normalize following treatment with selective serotonin reuptake inhibitors (SSRIs).
Broekhoven, F. van, Verkes, R.J.
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General and Comparative Endocrinology, 2014
Bargmann-Scharrer's discovery of "neurosecretion" in the first half of the 20th century has since matured into the scientific discipline of neuroendocrinology. Identification of novel neurohormones, such as neuropeptides and neurosteroids, is essential for the progress of neuroendocrinology.
Kazuyoshi, Tsutsui, Shogo, Haraguchi
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Bargmann-Scharrer's discovery of "neurosecretion" in the first half of the 20th century has since matured into the scientific discipline of neuroendocrinology. Identification of novel neurohormones, such as neuropeptides and neurosteroids, is essential for the progress of neuroendocrinology.
Kazuyoshi, Tsutsui, Shogo, Haraguchi
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Biosynthesis and action of neurosteroids
Brain Research Reviews, 2001Over the past decade, it has become clear that the brain, like the gonad, adrenal and placenta, is a steroidogenic organ. However, unlike classic steroidogenic tissues, the synthesis of steroids in the nervous system requires the coordinate expression and regulation of the genes encoding the steroidogenic enzymes in several different cell types ...
S H, Mellon +2 more
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Neurosteroids: Beginning of the story
2001Neurosteroids are synthetisized in the central and the peripheral nervous system, in glial cells, and also in neurons, from cholesterol or steroidal precursors imported from peripheral sources. They include 3 beta-hydroxy-delta 5-compounds, such as pregnenolone (PREG) and dehydroepiandrosterone, their sulfate esters, and compounds known as reduced ...
E E, Baulieu, P, Robel, M, Schumacher
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Neurosteroids: recent findings
Brain Research Reviews, 2001The term neurosteroid applies to those steroids that are synthesized in the nervous system, from cholesterol or other blood-borne steroidal precursors, and that accumulate in the nervous system to levels that are at least in part independent from steroidogenic gland secretion.
E, Plassart-Schiess, E E, Baulieu
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Neurosteroids and Sporadic Alzheimers Disease
Current Alzheimer Research, 2008A reduction of neurosteroids in the brain may initiate sporadic Alzheimer's disease (AD) which comprises >99% of all AD cases. AD research is currently focused on aberrant amyloid precursor protein (APP) processing and the hyper-phosphorylation of tau protein. This is based on early-onset genetic and pathological observations clearly showing that these
Barry, Guy, Ross, Ian L.
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The Neuropsychopharmacological Potential of Neurosteroids
1999Steroid hormone action involves binding of the steroids to their respective intracellular receptors, which in turn change their conformation by dissociation from the heat-shock proteins, translocate to the nucleus, and there bind to the respective response elements that are located in the regulatory regions of target promoters (1).
Rupprecht, R., Friess, E., Holsboer, F.
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Sheng li ke xue jin zhan [Progress in physiology], 2000
The term "neurosteroids" applies to those steroids that are synthesized in nervous system independent of supply by peripheral endocrine glands. The neurosteroids biosynthetic pathway, the mechanisms of neurosteroids in regulating neuronal activities and the neuromodulatory effects of neurosteroids, particularly the bimodal regulation of GABAA receptors,
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The term "neurosteroids" applies to those steroids that are synthesized in nervous system independent of supply by peripheral endocrine glands. The neurosteroids biosynthetic pathway, the mechanisms of neurosteroids in regulating neuronal activities and the neuromodulatory effects of neurosteroids, particularly the bimodal regulation of GABAA receptors,
openaire +1 more source