Results 121 to 130 of about 5,285 (165)
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Dehydroepiandrosterone – a neurosteroid
European Journal of Clinical Investigation, 2000Dehydroepiandrosteone (DHEA) and its sulfate ester (DHEAS) are the major secretory products of the human adrenal glands and serve as precursors for both androgenic and estrogenic steroids. DHEA/S concentrations are particularly high in the brain, and DHEA/S and related steroids can be synthesized de novo in brain glial cells.
Friess, E. +3 more
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Neurosteroids and Epileptogenesis
Journal of Neuroendocrinology, 2013Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures occur. This concept has been recently re‐evaluated to include exacerbation of clinically‐manifested epilepsy. Thus, in patients affected by pharmacoresistant seizures, the progression toward a worse condition may be viewed as the result of a durable ...
BIAGINI, Giuseppe +6 more
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Nongenomic effects of neurosteroids
Gynecological Endocrinology, 1998 This review summarizes the current knowledge about the synthesis, the mechanism of action, and the effects of neurosteroids in the central nervous system. Particular attention is paid to the nongenomic actions of neurosteroids, which are discussed in relation to their clinical relevance for physiological and pathological states.
Alberto Revelli +2 more
exaly +3 more sources
2001
In this chapter, we review techniques used for the analysis of neurosteroids and discuss the advantages and disadvantages of each method. Because radioimmunoassay (RIA) procedures are well known, we focus more on the relatively recent mass spectrometric methods used for analyzing neurosteroids and their sulfates.
A A, Alomary +2 more
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In this chapter, we review techniques used for the analysis of neurosteroids and discuss the advantages and disadvantages of each method. Because radioimmunoassay (RIA) procedures are well known, we focus more on the relatively recent mass spectrometric methods used for analyzing neurosteroids and their sulfates.
A A, Alomary +2 more
openaire +2 more sources
2001
Neurosteroid production may be a mechanism to counteract the negative effects of stress and return organisms toward homeostasis. Stress induces an increase in neurosteroid production. Neurosteroids affect two of the most widely distributed neurotransmitter and receptor systems in the central nervous system (CNS): gamma-aminobutyric acid (GABA) and ...
S R, Engel, K A, Grant
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Neurosteroid production may be a mechanism to counteract the negative effects of stress and return organisms toward homeostasis. Stress induces an increase in neurosteroid production. Neurosteroids affect two of the most widely distributed neurotransmitter and receptor systems in the central nervous system (CNS): gamma-aminobutyric acid (GABA) and ...
S R, Engel, K A, Grant
openaire +2 more sources
Neurosteroids as regulators of neuroinflammation
Frontiers in Neuroendocrinology, 2019 Neuroinflammation is a physiological protective response in the context of infection and injury. However, neuroinflammation, especially if chronic, may also drive neurodegeneration. Neurodegenerative diseases, such as multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and traumatic brain injury (TBI), display inflammatory ...
Canelif Yilmaz +2 more
exaly +4 more sources
Neurosteroids and the mesocorticolimbic system
Neuroscience & Biobehavioral Reviews, 2023The mesocorticolimbic system coordinates executive functions, such as working memory and behavioral flexibility. This circuit includes dopaminergic projections from the ventral tegmental area to the nucleus accumbens and medial prefrontal cortex. In this review, we summarize evidence that cells in multiple nodes of the mesocorticolimbic system produce ...
Désirée R, Seib +4 more
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Neurosteroids: Biosynthesis and Function
1994The term "neurosteroids" applies to those steroids that are both synthesized in the nervous system, either de novo from cholesterol or from steroid hormone precursors, and that accumulate in the nervous system to levels at least in part independent of steroidogenic gland secretion rates.
P, Robel, E E, Baulieu
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