Results 31 to 40 of about 12,871 (217)
Probing GABAA receptors with inhibitory neurosteroids [PDF]
Neuropharmacology, 2018 &ggr;‐aminobutyric acid type A receptors (GABAARs) are important components of the central nervous system and they are functionally tasked with controlling neuronal excitability.
S. Seljeset +3 more
semanticscholar +2 more sources
The endogenic neurosteroid system and its role in the pathogenesis and therapy of mental disorders
Research Results in Pharmacology, 2023 Introduction: Although neurosteroids have been relatively recently discovered, their significant role in the neurochemical processes and pathogenesis of a number of psychiatric and neurological disorders is now quite clear.
Sakeena P. Bairamova +7 more
doaj +1 more source
Journal of Pharmacology and Experimental Therapeutics, 2023 This article describes recent advances in the use of neurosteroids as novel anticonvulsants for refractory status epilepticus (RSE) and as medical countermeasures (MCs) for organophosphates and chemical nerve agents (OPNAs).
D. Reddy
semanticscholar +1 more source
Neurosteroids: mechanistic considerations and clinical prospects
Neuropsychopharmacology, 2023 Like other classes of treatments described in this issue’s section, neuroactive steroids have been studied for decades but have risen as a new class of rapid-acting, durable antidepressants with a distinct mechanism of action from previous antidepressant
J. Maguire, S. Mennerick
semanticscholar +1 more source
Neurosteroids and epilepsy [PDF]
Current Opinion in Neurology, 2010 Neurosteroids are a family of compounds synthesized directly in the brain by transforming cholesterol into pregnenolone, which is then converted to compounds such as allopregnanolone and allotetrahydrodeoxycorticosterone. In view of their ability to modulate neurotransmission, neurosteroids may influence the clinical course of epileptic disorders.
Giuseppe Biagini +2 more
openaire +4 more sources
Pharmacology and Therapeutics, 2022 Alcohol Use Disorder (AUD) is a multifaceted relapsing disorder that is commonly comorbid with psychiatric disorders, including anxiety. Alcohol exposure produces a plethora of effects on neurobiology.
Eleonora Gatta +4 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Even though major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) are among the most prevalent and incapacitating mental illnesses in the world, their diagnosis still relies solely on the characterization of subjective symptoms (many ...
F. B. Almeida, H. M. T. Barros, G. Pinna
semanticscholar +1 more source
iScience, 2020 Summary: Neuroactive steroids, termed neurosteroids, are synthesized locally in the brain and influence biological functions including cognition and behavior.
Kanako Maehata +8 more
doaj +1 more source
Neurosteroids and early-life programming: An updated perspective
Current Opinion in Endocrine and Metabolic Research, 2022 Early-life stress can lead to detrimental offspring outcomes, including an increased risk for mood disorders and hypothalamic–pituitary–adrenal axis dysregulation. Neurosteroids bind to ligand-gated neurotransmitter receptors, rapidly modulating neuronal
Y. Sze, P. Brunton
semanticscholar +1 more source
, 2008 The neurosteroids constitute a group of powerful hormones synthesized and acting in the central nervous system. They participate in a number of important central processes, such as memory and learning, mood and neuroprotection.
Nyberg, Fred +3 more
core +8 more sources