Results 21 to 30 of about 12,871 (217)
Neurosteroids and GABAergic signaling in health and disease
Biomolecular Concepts, 2013 Endogenous neurosteroids such as allopregnanolone, allotetrahydrodeoxycorticosterone, and androstanediol are synthesized either de novo in the brain from cholesterol or are generated from the local metabolism of peripherally derived progesterone or ...
Jamie Maguire
exaly +2 more sources
Neurosteroids and GABAA receptor interactions: a focus on stress [PDF]
Frontiers in Neuroscience, 2011 Since the pioneering discovery of the rapid CNS depressant actions of steroids by the father of stress, Hans Seyle 70 years ago, brain-derived neurosteroids have emerged as powerful endogenous modulators of neuronal excitability.
Benjamin George Gunn +3 more
doaj +2 more sources
Frontiers in Neuroendocrinology, 2019 The pregnenolone-progesterone-allopregnanolone pathway is receiving increasing attention in research on the role of neurosteroids in pathophysiology, particularly in stress-related and drug use disorders. These disorders involve an allostatic change that
Monique Vallée, Giovanni Tomaselli
exaly +2 more sources
Chronic Stress, 2018 Allopregnanolone and pregnanolone—neurosteroids synthesized from progesterone in the brain, adrenal gland, ovary and testis—have been implicated in a range of neuropsychiatric conditions including seizure disorders, post-traumatic stress disorder, major ...
Jennifer J. Liang, Ann M. Rasmusson
doaj +2 more sources
PLoS ONE, 2007 BackgroundThe role of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in the regulation of energy metabolism and immune system by locally reactivating glucocorticoids has been extensively studied.
Lyubomir G Nashev +7 more
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The role of neurosteroids in the pathogenesis of hepatic encephalopathy [PDF]
Medicinski Podmladak, 2016 Hepatic Encephalopathy (HE) represents a neuropsychiatric syndrome caused by acute or chronic liver failure. Hyperammonemia plays a pivotal role in the development of HE through modulation of neurotransmission, oxidative stress, neuroinflammation ...
Mladenović Dušan +2 more
doaj +2 more sources
Migraine and cluster headache show impaired neurosteroids patterns
The Journal of Headache and Pain, 2019 Background Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migraine.
Angela Koverech +13 more
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Neurosteroids and sporadic Alzheimer's disease
Current Alzheimer Research, 2008 A reduction of neurosteroids in the brain may initiate sporadic Alzheimer's disease (AD) which comprises > 99% of all AD cases. AD research is currently focused on aberrant amyloid precursor protein (APP) processing and the hyper-phosphorylation of tau ...
Barry, Guy, Ross, Ian L.
core +6 more sources
New Biosynthesis and Biological Actions of Avian Neurosteroids [PDF]
Journal of Experimental Neuroscience, 2013 De novo neurosteroidogenesis from cholesterol occurs in the brain of various avian species. However, the biosynthetic pathways leading to the formation of neurosteroids are still not completely elucidated.
Kazuyoshi Tsutsui +7 more
doaj +2 more sources
Researh Topic : Neurosteroids [PDF]
Frontiers in Endocrinology, 2012 Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration does not affect the concentration of pregnenolone, dehydroepiandrosterone, and their sulfate esters in the ...
Hubert eVaudry, Kazuyoshi eTsutsui
doaj +3 more sources