Results 21 to 30 of about 5,285 (165)
Pineal Neurosteroids: Biosynthesis and Physiological Functions
Frontiers in Endocrinology, 2020 Similar to the adrenal glands, gonads, and placenta, vertebrate brains also produce various steroids, which are known as “neurosteroids.” Neurosteroids are mainly synthesized in the hippocampus, hypothalamus, and cerebellum; however, it has recently been
Shogo Haraguchi, Kazuyoshi Tsutsui
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Treatment of Postpartum Depression with Neurosteroids
Neurologijos seminaraiNeurosteroids, such as allopregnanolone, are primarily synthesized substances in the central nervous system which influence processes occurring in the brain.
Reda Stankevičiūtė, Robertas Strumila
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Neurosteroids and GABAA receptor interactions: a focus on stress
Frontiers in Neuroscience, 2011 Since the pioneering discovery of the rapid CNS depressant actions of steroids by the father of stress, Hans Seyle 70 years ago, brain-derived neurosteroids have emerged as powerful endogenous modulators of neuronal excitability.
Benjamin George Gunn +3 more
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Neurosteroid biosynthesis and function in the brain of domestic birds
Frontiers in Endocrinology, 2011 It is now established that the brain and other nervous systems have the capability of forming steroids de novo, the so-called neurosteroids. The pioneering discovery of Baulieu and his colleagues, using rodents, has opened the door to a new research ...
Kazuyoshi eTsutsui
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The brain of teleost fish, a source and a target of sexual steroids
Frontiers in Neuroscience, 2011 Neurosteroids are defined as steroids de novo synthesized in the central nervous system. While the production of neurosteroids is well documented in mammals or amphibians, there is little information in teleosts, the largest group of fish.
Nicolas eDiotel +6 more
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Sexual steroids and functions of the brain [PDF]
Гинекология, 2017 Neurosteroids are endogenous modulators of nervous excitability. There is increasing evidence of sedative, anxiolytic, analgesic and anticonvulsant properties of neurosteroids.
N N Stenyaeva +3 more
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Synthetic neurosteroids on brain protection
Neural Regeneration Research, 2015 Neurosteroids, like allopregnanolone and pregnanolone, are endogenous regulators of neuronal excitability. Inside the brain, they are highly selective and potent modulators of GABA A receptor activity.
Mariana Rey, Héctor Coirini
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Zuranolone: A case study in (regulatory) rush to judgement?
British Journal of Clinical Pharmacology, EarlyView.Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove +4 more
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Cells, 2020 Neuroinflammation, whose distinctive sign is the activation of microglia, is supposed to play a key role in the development and progression of neurodegenerative diseases.
Rossella Avallone +7 more
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Frontiers in Neuroscience, 2021 Diverse populations of GABAA receptors (GABAARs) throughout the brain mediate fast inhibitory transmission and are modulated by various endogenous ligands and therapeutic drugs.
David Castellano +2 more
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