Results 21 to 30 of about 210,811 (163)
The TRPP2-dependent channel of renal primary cilia also requires TRPM3.
PLoS ONE, 2019 Primary cilia of renal epithelial cells express several members of the transient receptor potential (TRP) class of cation-conducting channel, including TRPC1, TRPM3, TRPM4, TRPP2, and TRPV4.
Steven J Kleene +6 more
doaj +1 more source
Molecules, 2022 Accurate measurement of sulfated steroid metabolite concentrations can not only enable the elucidation of the mechanisms regulating steroid metabolism, but also lead to the diagnosis of various related diseases.
Hiroyuki Kataoka, Daiki Nakayama
doaj +1 more source
Higher steroid sulfation is linked to successful weight loss in obese children
Endocrine Connections, 2018 Objective: Little information is available on the steroid sulfates profile in obese children. Therefore, we examined whether sulfated steroids are linked with weight status and associated comorbidities in obese children.
Thomas Reinehr +3 more
doaj +1 more source
Molecular Medicine, 2018 Background Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME) is a debilitating disorder that is accompanied by reduced cytotoxic activity in natural killer (NK) cells. NK cells are an essential innate immune cell, responsible for recognising
Hélène Cabanas +5 more
doaj +1 more source
Cells, 2020 Neuroinflammation, whose distinctive sign is the activation of microglia, is supposed to play a key role in the development and progression of neurodegenerative diseases.
Rossella Avallone +7 more
doaj +1 more source
Pregnenolone sulfate analogues differentially modulate GABAA receptor closed/desensitised states [PDF]
, 2023 BACKGROUND AND PURPOSE: GABAA receptors are regulated by numerous classes of allosteric modulators. However, regulation of receptor macroscopic desensitisation remains largely unexplored and may offer new therapeutic opportunities.
Shehata, Mohamed A +6 more
core +1 more source
GABAergic neuroactive steroids: a new frontier in bipolar disorders?
Behavioral and Brain Functions, 2012 Neurosteroids are synthesized in the brain and modulate brain excitability. There is increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their influence on mood.
Carta Mauro Giovanni +2 more
doaj +1 more source
Activation of ciliary channels by pregnenolone sulfate.
, 2019 (A) The top recording shows the activity of a single ciliary channel observed while recording in the standard solutions (with 0.1 μM cytoplasmic free Ca2+). The bottom recording shows increased channel activity in the same cilium 5 min after perfusion of
Bradley P. Dixon (356752) +6 more
core +1 more source
Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]
, 2006 Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Eser, Daniela +9 more
core +1 more source
Metabolism of pregnenolone-4-14C and pregnenolone-7[alpha]-3H sulfate by the Macaca mulatta fetal adrenal in vitro [PDF]
, 1971 These studies were initiated to ascertain the feasibility of utilizing the fetal monkey adrenal as a model for further studies on comparative steroid metabolism at various periods of gestation.
Snyder, Donald L. +3 more
core +1 more source