Results 41 to 50 of about 210,811 (163)
Bacterial indole‐3‐butyric acid promotes fish PUFA synthesis
iMetaOmics, Volume 3, Issue 3, September 2026.Polyunsaturated fatty acids (PUFAs) are essential nutrients in aquatic products, yet the contribution of gut microbiota‐derived metabolites to PUFA biosynthesis remains largely unknown. In this study, a gut‐derived Bacillus strain was identified to enhance PUFA accumulation via indole‐3‐butyric acid (IBA) production.
Ruojing Li +10 more
wiley +1 more source
eLife, 2020 Developmental and epileptic encephalopathies (DEE) are a heterogeneous group of disorders characterized by epilepsy with comorbid intellectual disability.
Evelien Van Hoeymissen +5 more
doaj +1 more source
TRPM3-Induced Gene Transcription Is under Epigenetic Control
Pharmaceuticals, 2022 Transient receptor potential M3 (TRPM3) cation channels regulate numerous biological functions, including gene transcription. Stimulation of TRPM3 channels with pregnenolone sulfate activates stimulus-responsive transcription factors, which bind to short
Gerald Thiel, Oliver G. Rössler
doaj +1 more source
Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak +4 more
wiley +1 more source
Brazilian Journal of Psychiatry, 2007 OBJECTIVE: The objective of the present study was to investigate the effect of epipregnanolone on the influence of neurosteroids on the development of rapid tolerance to the motor impairing and hypothermic effects of ethanol. METHOD: Experiment 1: on Day
Adriana Dias Elpo Barbosa +1 more
doaj +1 more source
Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)
Phytotherapy Research, Volume 40, Issue 8, Page 4880-4897, August 2026.ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley +1 more source
Neurosteroid Transport in the Brain: Role of ABC and SLC Transporters
Frontiers in Pharmacology, 2018 Neurosteroids, comprising pregnane, androstane, and sulfated steroids can alter neuronal excitability through interaction with ligand-gated ion channels and other receptors and have therefore a therapeutic potential in several brain disorders.
Markus Grube +2 more
doaj +1 more source
Bipolar Disorders, Volume 28, Issue 5, August 2026.ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders +21 more
wiley +1 more source
Dependence of channel activation on voltage and pregnenolone sulfate concentration.
, 2019 (A) Channel open probability was measured as a function of membrane potential. Cytoplasmic solutions contained 0.1 μM free Ca2+. The pipette contained pregnenolone sulfate (0 μM to 75 μM as indicated) dissolved in an external solution that also contained
Bradley P. Dixon (356752) +6 more
core +1 more source
NEUROBIOLOGICAL EFFECTS OF DHEA IN FEMALES WITH SPECIAL REFERENCE TO SEXUAL FUNCTION: FINDINGS FROM IN-VIVO AND HUMAN STUDIES [PDF]
, 2012 Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, together represent the most abundant steroid hormones in the human body. Nonetheless, their physiological significance, their mechanisms of action and their possible roles in human disease are ...
PLUCHINO, NICOLA
core +1 more source