Results 61 to 70 of about 210,811 (163)

Observed Weight Gain in Patients With Pulmonary Arterial Hypertension Treated With Sotatercept

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Sotatercept, an activin signaling inhibitor for pulmonary arterial hypertension (PAH), has demonstrated significant improvements in clinical outcomes though its off‐target effects are still an area for discovery. Anecdotal increases in total body weight not attributable to fluid retention have been observed.
Rebecca A. Greene, Darlene Tat, Allyson Sherman‐Roe, Tiffaney Cayton, Jacqueline Lopes, Alexander Jorrin, James Klinger, Christopher J. Mullin, Kathryn Needle, William M. Oldham, Crossandra Osgood, Navneet Singh, Corey E. Ventetuolo   +12 more
wiley   +1 more source

Influência dos neuroesteróides sobre a tolerância ao etanol em camundongos / [PDF]

, 1999
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências ...
Barbosa, Adriana Dias Elpo
core  

The role of pregnenolone sulfate in modulating neuronal excitability [PDF]

, 2013
Thesis (M.A.)--Boston UniversityThe central nervous system operates through a tightly balanced relationship of excitatory and inhibitory synaptic transmission.
Sowa, Calan B.
core   +1 more source

Enteromorpha prolifera Polysaccharide Alleviates Type 2 Diabetes via the Gut Microbiota–Liver Axis to Modulate Cholesterol Metabolism

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Enteromorpha prolifera polysaccharides may help restore lipid metabolism homeostasis by gently remodeling the gut microbiota to enrich beneficial bacteria and SCFAs, which in turn appears to modulate hepatic functions through the portal vein by downregulating cholesterol synthesis and promoting its metabolism. This coordinated process potentially leads
Liuying Zhu, Xusheng Wen, Wenrong Zhu, Xueqian Hu, Yanqun Xu, Xin Peng   +5 more
wiley   +1 more source

Altitude‐Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Feiyun Huang, Zexiu Zhang, Yanni Zhao, Sen Ye, Maoyuan Gan, Xuxin Li, Yele Zhang, Lei Chen, Yushuo Zhang, Lingxi Chen, Ting Wang, Jinming Huang, Xiuyue Zhang   +12 more
wiley   +1 more source

Biotechnological aspects of sulfate reduction with methane as electron donor [PDF]

, 2010
Biological sulfate reduction can be used for the removal and recovery of oxidized sulfur compounds and metals from waste streams. However, the costs of conventional electron donors, like hydrogen and ethanol, limit the application possibilities.
Meulepas, Roel J.W., Piet N. L. Lens, Alfons J. M. Stams, Stams, Alfons J.M., Roel J. W. Meulepas, Stams, A.J.M., Meulepas, R.J.W., Lens, P.N.L., Lens, Piet N.L.   +8 more
core   +1 more source

Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels

Frontiers in Pharmacology, 2019
The sigma 1 receptor (σ1R) and the mu-opioid receptor (MOR) regulate the transient receptor potential (TRP) V1 calcium channel. A series of proteins are involved in the cross-regulation between MORs and calcium channels like the glutamate N-methyl-D ...
Elsa Cortés-Montero, Pilar Sánchez-Blázquez, Yara Onetti, Manuel Merlos, Javier Garzón   +4 more
doaj   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia [PDF]

, 2009
The neurosteroid pregnenolone and its sulfated derivative enhance learning and memory in rodents. Pregnenolone sulfate also positively modulates NMDA receptors and could thus ameliorate hypothesized NMDA receptor hypofunction in schizophrenia ...
Payne, Victoria M., Patrizia Porcu, Marx, Christine E., Jeffrey A Lieberman, Porcu, Patrizia, Dunn, Lawrence, Bradford, Daniel W., Strauss, Jennifer L., Daniel W Bradford, A Leslie Morrow, Christine E Marx, Lieberman, Jeffrey A., Savitz, Adam J., Morrow, A. Leslie, Shampine, Lawrence J., Robert M Hamer, Hamer, Robert M., Leimone, Linda A., Lawrence J Shampine, Jason D Kilts, Naylor, Jennifer C., Linda A Leimone, Robert W Buchanan, Victoria M Payne, Keefe, Richard S.E., Lawrence Dunn, Buchanan, Robert W., Jennifer L Strauss, Richard S E Keefe, Jennifer C Naylor, Adam J Savitz, Kilts, Jason D.   +31 more
core   +1 more source

(r,r)-disynephrine ether bis(hydrogen sulfate) [PDF]

, 2009
The asymmetric unit of the title compound [systematic name: (R, R)-2,4-bis(4-hydroxyphenyl)-N,N'-dimethyl-3-oxapentane-1,5- diammonium bis(hydrogen sulfate)], C18H26N2O32+center dot-2HSO(4)(-), contains one half-cation and one hydrogen sulfate anion. The
Arbuckle, William, Morrison, Catriona A., Catriona A. Morrison, Arbuckle, W., Kennedy, A.R., Alan R. Kennedy, Morrison, C.A., Kennedy, Alan R., William Arbuckle   +8 more
core   +2 more sources