A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3 [PDF]
Communications ChemistryTransient Receptor Potential Melastatin 3 (TRPM3) is a non-selective, Ca2+-permeable ion channel that plays a pivotal role in peripheral thermosensation and nociception.
Katharina Held +12 more
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Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome [PDF]
Frontiers in MedicineIntroductionMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic disease hallmarked by multiple systemic symptoms, such as neurocognitive, respiratory, immunological, gastrointestinal, and cardiovascular impairment, which worsen ...
Etianne Martini Sasso +10 more
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ATP release mediated by TRPM3 enhances invasion in glioblastoma [PDF]
Animal Cells and SystemsGlioblastoma (GBM) is the most aggressive and lethal form of primary brain tumor, characterized by uncontrolled proliferation and invasion into surrounding brain tissue.
Kkot Garam Bae +11 more
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Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3 [PDF]
Nature CommunicationsThe transient receptor potential melastatin 3 (TRPM3) channel is a key mediator of peripheral pain signaling, and pathogenic mutations in TRPM3 are linked to neurodevelopmental delay and epilepsy.
Bahar Bazeli +12 more
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A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens
CellsTRPM3 belongs to the melastatin sub-family of transient receptor potential (TRPM) cation channels and has been shown to function as a steroid-activated, heat-sensitive calcium ion (Ca2+) channel.
Mohammad Shahidullah +2 more
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Deficient TRPM3-linked mitochondrial Ca2+ influx in natural killer cells associated with myalgic encephalomyelitis/chronic fatigue syndrome [PDF]
BMC ImmunologyIntroduction Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic illness, commonly associated with dysregulation of the immune system including reduced cytotoxicity of natural killer (NK) cells and post-exertional neuroimmune ...
Chandi Tabeth Magawa +3 more
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Sex difference in TRPM3 channel functioning in nociceptive and vascular systems: an emerging target for migraine therapy in females? [PDF]
The Journal of Headache and PainTransient Receptor Potential Melastatin 3 (TRPM3) channels are Ca2+ permeable ion channels that act as polymodal sensors of mechanical, thermal, and various chemical stimuli.
Georgii Krivoshein +4 more
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Stimulus–Transcription Coupling of TRPM3 Channels: A Signaling Pathway from the Plasma Membrane to the Nucleus [PDF]
BiomoleculesTransient receptor potential melastatin-3 (TRPM3) channels are cation channels activated by heat and chemical ligands. TRPM3 regulates heat sensation, secretion, neurotransmitter release, iris constriction, and tumor promotion.
Gerald Thiel, Oliver G. Rössler
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Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat [PDF]
The EMBO JournalCopine-6 is a calcium-sensitive phospholipid-binding protein of the evolutionarily conserved Copine family. In the central nervous system, Copine-6 regulates function of some neurotransmitter receptors and structural plasticity of dendritic spines ...
Yiting Gao +9 more
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Stimulation of Transient Receptor Potential Channels TRPM3 and TRPM8 Increases Human Prostaglandin Endoperoxide Synthase-2 Promoter Activity [PDF]
MoleculesThe transient receptor potential channels TRPM3 and TRPM8 are cation channels that regulate numerous cellular activities, including thermo- and pain sensation.
Nikolas Brandmeier +2 more
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