Results 31 to 40 of about 2,388 (162)

Probiotic Supplementation as an Alternative to Antibiotics in Bovine Sperm Cryopreservation: Effects on Motility, Oxidative Stress and Apoptosis. [PDF]

Reprod Domest Anim
ABSTRACT This study aimed to evaluate the effects of probiotic supplementation on bovine sperm cryopreservation by assessing post‐thaw spermatological and biochemical parameters. Twenty‐four ejaculations were collected from four Simmental bulls using the artificial vagina method.
Ömür AD, Çelebi D, Akarsu SA, Apaydin Yildirim B, Uçak G, Acisu TC, Aydin MA, Başer S, Çelebi Ö, Koca RH, Arkali G, Hussain T.   +11 more
europepmc   +2 more sources

Production of a specific extracellular inhibitor of TRPM3 channels [PDF]

British Journal of Pharmacology, 2008
Background and purpose:Isoform‐specific ion channel blockers are useful for target validation in drug discovery and can provide the basis for new therapeutic agents and aid in determination of physiological functions of ion channels. The aim of this study was to generate a specific blocker of human TRPM3 channels as a tool to help investigations of ...
J, Naylor, C J, Milligan, F, Zeng, C, Jones, D J, Beech   +4 more
openaire   +2 more sources

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

eLife, 2017
Opioids, agonists of µ-opioid receptors (µORs), are the strongest pain killers clinically available. Their action includes a strong central component, which also causes important adverse effects.
Sandeep Dembla, Marc Behrendt, Florian Mohr, Christian Goecke, Julia Sondermann, Franziska M Schneider, Marlene Schmidt, Julia Stab, Raissa Enzeroth, Michael G Leitner, Paulina Nuñez-Badinez, Jochen Schwenk, Bernd Nürnberg, Alejandro Cohen, Stephan E Philipp, Wolfgang Greffrath, Moritz Bünemann, Dominik Oliver, Eleonora Zakharian, Manuela Schmidt, Johannes Oberwinkler   +20 more
doaj   +1 more source

Migraine-relevant sex-dependent activation of mouse meningeal afferents by TRPM3 agonists

The Journal of Headache and Pain, 2022
Background Migraine is a common brain disorder that predominantly affects women. Migraine pain seems mediated by the activation of mechanosensitive channels in meningeal afferents.
G. Krivoshein, E. A. Tolner, van den Maagdenberg AMJM, R. A. Giniatullin   +3 more
doaj   +1 more source

Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients

Journal of Translational Medicine, 2022
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the pathomechanism of ME/CFS remains elusive, reduced natural killer (NK) cell cytotoxic function is a consistent immunological ...
Natalie Eaton-Fitch, Stanley Du Preez, Hélène Cabanas, Katsuhiko Muraki, Donald Staines, Sonya Marshall-Gradisnik   +5 more
doaj   +1 more source

Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Frontiers in Immunology, 2019
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a seriously long-term and debilitating illness of unknown cause hallmarked by chronic pain and fatigue, memory and concentration impairment, and inflammation.
Helene Cabanas, Helene Cabanas, Helene Cabanas, Katsuhiko Muraki, Katsuhiko Muraki, Donald Staines, Donald Staines, Donald Staines, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik   +10 more
doaj   +1 more source

Pore and Gating Properties of TRPM3 Isoforms [PDF]

Biophysical Journal, 2012
TRPM3 has recently been identified as a nociceptor channel in sensory neurons, where it mediates pain responses to noxious heat and the neurosteroid pregnenolone sulphate (PS). Several TRPM3 splice isoforms have been identified, including splice variants with differences in the pore region exhibiting concommitant differences in permeability properties.
Vriens, Joris, Voets, Thomas
openaire   +1 more source

Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients

Molecular Medicine, 2018
Background Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME) is a debilitating disorder that is accompanied by reduced cytotoxic activity in natural killer (NK) cells. NK cells are an essential innate immune cell, responsible for recognising
Hélène Cabanas, Katsuhiko Muraki, Natalie Eaton, Cassandra Balinas, Donald Staines, Sonya Marshall-Gradisnik   +5 more
doaj   +1 more source

Description of a novel patient with the TRPM3 recurrent p.Val837Met variant

European Journal of Medical Genetics, 2021
De novo heterozygous missense mutations in TRPM3 have been shown to cause developmental and epileptic encephalopathies (DEE). It is a very rare condition, as only 9 patients have been described to date. We report here a novel patient carrying the recurrent p.Val837Met variant and presenting new clinical features, such as trigonocephaly, expanding the ...
Gauthier, Lucas, Chatron, Nicolas, Cabet, Sara, Labalme, Audrey, Carneiro, Maryline, Poirot, Isabelle, Delvert, Céline, Gleizal, Arnaud, Lesca, Gaetan, Putoux, Audrey   +9 more
openaire   +4 more sources

The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients

Journal of Translational Medicine, 2021
Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious multifactorial disorder. The origin remains ambiguous, however reduced natural killer (NK) cell cytotoxicity is a consistent immunological feature of ME/CFS.
Natalie Eaton-Fitch, Hélène Cabanas, Stanley du Preez, Donald Staines, Sonya Marshall-Gradisnik   +4 more
doaj   +1 more source