Results 51 to 60 of about 2,388 (162)

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat [PDF]

Neuron, 2011
Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca(2+)-permeable nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 by the neuroactive steroid pregnenolone sulfate (PS), but its in vivo gating mechanisms and functions remained poorly understood.
Vriens, Joris, Owsianik, Grzegorz, Hofmann, Thomas, Philipp, Stephan E., Stab, Julia, Chen, Xiaodi, Benoit, Melissa, Xue, Fenqin, Janssens, Annelies, Kerselaers, Sara, Oberwinkler, Johannes, Vennekens, Rudi, Gudermann, Thomas, Nilius, Bernd, Voets, Thomas   +14 more
openaire   +2 more sources

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

Primidone inhibits TRPM3 and attenuates thermal nociception in vivo [PDF]

Pain, 2017
AbstractThe melastatin-related transient receptor potential (TRP) channel TRPM3 is a nonselective cation channel expressed in nociceptive neurons and activated by heat. Because TRPM3-deficient mice show inflammatory thermal hyperalgesia, pharmacological inhibition of TRPM3 may exert antinociceptive properties.
Krügel, Ute, Straub, Isabelle, Beckmann, Holger, Schaefer, Michael   +3 more
openaire   +2 more sources

Genome‐Wide Association Studies for Anogenital Distance and Linear Type Traits in Gir Cattle

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Although linear type traits have been under selection in the Dairy Gir cattle for the past three decades, there are few studies exploring genetic architecture for these traits. The aim of this study was to identify candidate genes for anogenital distance and linear type traits in the Gir breed. For this study, the body measures of rump length (
Renata de Fátima Bretanha Rocha, Andréia Ferreira Machado, Fabrício Pilonetto, Marcos Vinícius Barbosa da Silva, Domingos Lollobrigida de Souza Netto, José Domingos Guimarães, Fábio Luiz Buranelo Toral, Victor E. Gomez Leon, Simone Eliza Facioni Guimarães   +8 more
wiley   +1 more source

Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients

Biological Research
BACKGROUND: Transient receptor potential melastatin 3 (TRPM3) cation channels are ubiquitously expressed by multiple cells and have an important regulatory role in calcium-dependent cell signalling to help maintain cellular homeostasis.
T. Nguyen, D. Staines, B. Nilius, P. Smith, S. Marshall-Gradisnik   +4 more
doaj   +1 more source

Molecular Regulations and Functions of the Transient Receptor Potential Channels of the Islets of Langerhans and Insulinoma Cells

Cells, 2020
Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1).
Md. Shahidul Islam
doaj   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms

eLife, 2020
Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca2+ permeable non-selective cation channel activated by heat and chemical agonists such as pregnenolone sulfate and CIM0216.
Siyuan Zhao, Yevgen Yudin, Tibor Rohacs
doaj   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Identification and classification of a new TRPM3 variant (γ subtype) [PDF]

The Journal of Physiological Sciences, 2019
TRPM3 is a non-selective cation channel that is activated by neural steroids such as pregnenolone sulfate, nifedipine, and clotrimazole. Despite the number of TRPM3 variants, few reports have described functional analyses of these different TRPM3 types. Here we identified a new TRPM variant from mouse dorsal root ganglion, termed TRPM3γ3. We classified
Uchida, Kunitoshi, Fukuta, Naomi, Yamazaki, Jun, Tominaga, Makoto   +3 more
openaire   +2 more sources