Results 71 to 80 of about 2,388 (162)

TRPM3_miR-204: a complex locus for eye development and disease

Human Genomics, 2020
First discovered in a light-sensitive retinal mutant of Drosophila, the transient receptor potential (TRP) superfamily of non-selective cation channels serve as polymodal cellular sensors that participate in diverse physiological processes across the ...
Alan Shiels
doaj   +1 more source

Mechanotransduction in the Brain: Soliton Theory, Piezo Receptors and MR Elastography in Headache Pathophysiology

Brain and Behavior, Volume 16, Issue 5, May 2026.
ABSTRACT Purpose This narrative review aims to explore how incorporating mechanical and thermal dimensions can complement and extend the classical Hodgkin‐Huxley (HH) model to enrich the understanding of headache and pain pathophysiology. Method This review examines the integration of three distinct concepts with the HH model.
Joan Crespi, Axel Karl Gottfrid Nyman, Erling Tronvik, Lanfranco Pellesi, Igor Petrušić, Tobias Navarro Schröder   +5 more
wiley   +1 more source

Investigation into the restoration of TRPM3 ion channel activity in post-COVID-19 condition: a potential pharmacotherapeutic target

Frontiers in Immunology
IntroductionRecently, we reported that post COVID-19 condition patients also have Transient Receptor Potential Melastatin 3 (TRPM3) ion channel dysfunction, a potential biomarker reported in natural killer (NK) cells from Myalgic Encephalomyelitis ...
Etianne Martini Sasso, Etianne Martini Sasso, Etianne Martini Sasso, Katsuhiko Muraki, Katsuhiko Muraki, Natalie Eaton-Fitch, Natalie Eaton-Fitch, Peter Smith, Peter Smith, Andrew Jeremijenko, Andrew Jeremijenko, Paul Griffin, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik   +13 more
doaj   +1 more source

Expression of Transient Receptor Potential Channel Genes and Their Isoforms in Alpha-Cells and Beta-Cells of Human Islets of Langerhans

Journal of Diabetes Research, 2022
Expression of the transient receptor potential (TRP) channel genes and their isoforms in the alpha-cells and the beta-cells of the human islets of Langerhans has not been studied in detail. In this study, we have analyzed the RNA sequencing data obtained
Gabriel M. Matos, Björn Andersson, Md. Shahidul Islam   +2 more
doaj   +1 more source

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Introduction Chronic primary low back pain (cpLBP) is a global health concern with poorly understood pathomechanisms, potentially involving spinal sensitization. The capsaicin receptor TRPV1 plays a crucial role in sensitization across pain models.
Vivian Blechschmidt, Bastian Schlickenrieder, Jonathan R. Husk, Ulrich Hoheisel, Handan Mörz, Rolf‐Detlef Treede, Wolfgang Greffrath   +6 more
wiley   +1 more source

Transient Receptor Potential Melastatin-3 (TRPM3) Mediates Nociceptive-Like Responses in Hydra vulgaris.

PLoS ONE, 2016
The ability of mammals to feel noxious stimuli lies in a heterogeneous group of primary somatosensory neurons termed nociceptors, which express specific membrane receptors, such as the Transient Receptor Potential (TRP) family.
Valentina Malafoglia, Lorenzo Traversetti, Floriano Del Grosso, Massimiliano Scalici, Filomena Lauro, Valeria Russo, Tiziana Persichini, Daniela Salvemini, Vincenzo Mollace, Massimo Fini, William Raffaeli, Carolina Muscoli, Marco Colasanti   +12 more
doaj   +1 more source

Schwann Cell TRPA1, a Proalgesic Ion Channel, Mediates Neuroinflammation and Fibromyalgia‐Associated Behaviours in Mice

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Cellular and molecular mechanisms contributing to TRPA1‐mediated mechanical and cold hypersensitivity and peripheral neuroinflammation in the reserpine‐induced experimental fibromyalgia model. (1) Macrophage‐originated reactive oxygen species (ROS; purple dots) target the transient receptor potential ankyrin 1 (TRPA1) channel localised in Schwann cells.
Evelyne Silva Brum, Maria Fernanda Pessano Fialho, Daniel Souza Monteiro de Araújo, Lorenzo Landini, Matilde Marini, Francesco De Logu, Romina Nassini, Sara Marchesan Oliveira   +7 more
wiley   +1 more source

Phosphoinositides as Co-Factors for the Ion Channel TRPM3 [PDF]

Biophysical Journal, 2015
The regulation of numerous ion channels by membrane lipids is widely known and well accepted. Of all the ion channel families, the modulation of members of Transient Receptor Potential (TRP) channels is complex, especially by phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
Badheka, Doreen, Borbiro, Istvan, Rohacs, Tibor   +2 more
openaire   +1 more source

TRPM3 Expression and Function in Vascular Smooth Muscle [PDF]

Biophysical Journal, 2010
The Transient Receptor Potential (TRP) channels form a diverse superfamily of cation channels. Currently there are few well characterised, selective, physiological regulators of TRP channels, which can impede the discovery of native channel functions. TRPM3, a member of the melastatin subfamily of TRP channels, is reported to form constitutively active
Naylor, Jacqueline, Li, Jing, Zeng, Fanning, Sukumar, Piruthivi, Majeed, Yasser, Milligan, Carol J., Kumar, Bhaskar, Porter, Karen E., Beech, David J.   +8 more
openaire   +1 more source

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone

Cell Calcium, 2012
Transient Receptor Potential Melastatin 3 (TRPM3) is a widely expressed calcium-permeable non-selective cation channel that is stimulated by high concentrations of nifedipine or by physiological steroids that include pregnenolone sulphate. Here we sought to identify steroids that inhibit TRPM3. Channel activity was studied using calcium-measurement and
Majeed, Yasser, Tumova, Sarka, Green, Ben L., Seymour, Victoria A.L., Woods, Daniel M., Agarwal, Anil K., Naylor, Jacqueline, Jiang, Shannon, Picton, Helen M., Porter, Karen E., O’Regan, David J., Muraki, Katsuhiko, Fishwick, Colin W.G., Beech, David J.   +13 more
openaire   +2 more sources