Results 81 to 90 of about 2,388 (162)

The TRPP2-dependent channel of renal primary cilia also requires TRPM3.

PLoS ONE, 2019
Primary cilia of renal epithelial cells express several members of the transient receptor potential (TRP) class of cation-conducting channel, including TRPC1, TRPM3, TRPM4, TRPP2, and TRPV4.
Steven J Kleene, Brian J Siroky, Julio A Landero-Figueroa, Bradley P Dixon, Nolan W Pachciarz, Lu Lu, Nancy K Kleene   +6 more
doaj   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

High Expression of miR-204 in Chicken Atrophic Ovaries Promotes Granulosa Cell Apoptosis and Inhibits Autophagy

Frontiers in Cell and Developmental Biology, 2020
Chicken atrophic ovaries have decreased volume and are indicative of ovarian failure, presence of a tumor, or interrupted ovarian blood supply. Ovarian tumor is accompanied by an increase in follicular atresia, granulosa cell (GC) apoptosis, and ...
Zhifu Cui, Lingbin Liu, Felix Kwame Amevor, Qing Zhu, Yan Wang, Diyan Li, Gang Shu, Yaofu Tian, Xiaoling Zhao   +8 more
doaj   +1 more source

Isoflavonoids and Epigenetic Modulation: Therapeutic Insights for Cancer Treatment

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
Venn diagram illustrating the epigenetic roles of three phytochemical groups—flavonoids, isoflavonoids, and pterocarpans. ABSTRACT Isolavonoides represent the second largest subgroup of flavonoids and have an influence on critical molecular pathways and restore cellular homeostasis, through the reprogramming of epigenetic regulatory mechanisms.
Eduardo de Moraes e Sousa, Maria Claudia dos Santos Luciano, Gabriel Caetano de Souza, Maria Francilene Souza Silva, Fátima de Cássia Evangelista de Oliveira, Sarah Sant'Anna Maranhão, Felipe Vasconcelos, Cristiana Libardi Miranda Furtado, Claudia do Ó Pessoa   +8 more
wiley   +1 more source

Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone

Journal of Translational Medicine
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with a broad overlap of symptomatology with Post-COVID Syndrome (PCS).
Matthias Löhn, Klaus Josef Wirth
doaj   +1 more source

Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants.

PLoS ONE
Gulf War Illness (GWI) is a chronic condition characterized by multisystem symptoms that still affect up to one-third of veterans who engaged in combat in the Gulf War three decades ago.
Sonya Marshall-Gradisnik, Etianne Martini Sasso, Natalie Eaton-Fitch, Peter Smith, James N Baraniuk, Katsuhiko Muraki   +5 more
doaj   +1 more source

TRPM3 Mediates Pain but Not Itch [PDF]

Biophysical Journal, 2020
Balazs Kelemen, Silvia Pinto, Erika Lisztes, Martin Hanyicska, Anita Vladár, Thomas Voets, Tamás Bíró, Balázs István Tóth   +7 more
openaire   +1 more source

Convergent Agonist and Heat Activation of Nociceptor TRPM3

Abstract Detecting noxious heat is vital for survival, triggering pain responses that protect against harm 1,2 . The TRPM3 channel is a key nociceptor for sensing noxious heat and a promising therapeutic target for pain treatment and neurological disorders such as epilepsy
Kumar, Sushant, Jin, Fei, Park, Sung Jin, Choi, Wooyoung, Keuning, Sarah I., Massimino, Richard P., Vu, Simon, Lü, Wei, Du, Juan   +8 more
openaire   +2 more sources

TRPM3, TRPM4, and TRPM5 as thermo-sensitive channels

The Journal of Physiological Sciences
Temperature detection is essential for the survival and perpetuation of any species. Thermoreceptors in the skin sense body temperature as well as the temperatures of ambient air and objects. Since Dr. David Julius and his colleagues discovered that TRPV1 is expressed in small-diameter primary sensory neurons, and activated by temperatures above 42 °C,
openaire   +2 more sources

401 Pruriceptive role of TRPM3 [PDF]

Journal of Investigative Dermatology, 2019
B. Kelemen, E. Lisztes, M. Hanyicska, A. Vladár, S. Pinto, T. Voets, T. Bíró, B.I. Tóth   +7 more
openaire   +1 more source