TRPM3 expression in mouse retina.
PLoS ONE, 2015 Transient receptor potential (TRP) channels constitute a large family of cation permeable ion channels that serve crucial functions in sensory systems by transducing environmental changes into cellular voltage and calcium signals.
R Lane Brown +7 more
doaj +5 more sources
Upregulation of TRPM3 in nociceptors innervating inflamed tissue
eLife, 2020 Genetic ablation or pharmacological inhibition of the heat-activated cation channel TRPM3 alleviates inflammatory heat hyperalgesia, but the underlying mechanisms are unknown.
Marie Mulier +7 more
doaj +4 more sources
TRPM3-Induced Gene Transcription Is under Epigenetic Control
Pharmaceuticals, 2022 Transient receptor potential M3 (TRPM3) cation channels regulate numerous biological functions, including gene transcription. Stimulation of TRPM3 channels with pregnenolone sulfate activates stimulus-responsive transcription factors, which bind to short
Gerald Thiel, Oliver G. Rössler
doaj +3 more sources
Case Report: Expanded delineation of phenotype of TRPM3-related neurodevelopmental disorders
Frontiers in PediatricsThe TRPM3 gene, part of the transient receptor potential (TRP) cation channel family, plays crucial roles in sensory perception and ion transport. Mutations in TRPM3 are linked to a range of neurological and developmental disorders.
Rafał Płoski +2 more
exaly +3 more sources
Low‐Dose naltrexone restored TRPM3 ion channel function in natural killer cells from long COVID patients [PDF]
Frontiers in Molecular BiosciencesIntroductionLong COVID is a multisystemic condition that includes neurocognitive, immunological, gastrointestinal, and cardiovascular manifestations, independent of the severity or duration of the acute SARS-CoV-2 infection.
Etianne Martini Sasso +10 more
doaj +2 more sources
Altered TRPM3-Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post-COVID-19 Condition Patients. [PDF]
Eur J ImmunolImmunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post‐COVID‐19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3‐mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC ...
Magawa CT +3 more
europepmc +2 more sources
Nuclear paraspeckle assembly transcript 1 promotes photophobia behavior in mice via miR-196a-5p/Trpm3 coupling [PDF]
The Journal of Headache and PainBackground The long noncoding RNA, NEAT1, is recognized as a key regulator of proinflammatory gene expression; Yet, its functional role in migraine remains unexplored, despite the central role of neuroinflammatory mechanisms in migraine pathophysiology ...
Zhuoan Huang +6 more
doaj +2 more sources
TRPM3 in Brain (Patho)Physiology [PDF]
Frontiers in Cell and Developmental Biology, 2021 Already for centuries, humankind is driven to understand the physiological and pathological mechanisms that occur in our brains. Today, we know that ion channels play an essential role in the regulation of neural processes and control many functions of the central nervous system.
Katharina Held +2 more
openaire +5 more sources
The Underlying Mechanism of Modulation of Transient Receptor Potential Melastatin 3 by protons
Frontiers in Pharmacology, 2021 Transient receptor potential melastatin 3 channel (TRPM3) is a calcium-permeable nonselective cation channel that plays an important role in modulating glucose homeostasis in the pancreatic beta cells.
Md Zubayer Hossain Saad +8 more
doaj +1 more source
Inhibition of TRPM3 by Primidone Provides a Potential Therapeutic Method for Adenomyosis Management [PDF]
Drug Design, Development and TherapyZhixing Jin,1,* Yaoming Peng,2,* He Zhang,1 Xiaoping He,2 Yi Zhang,1 Xin Pan,1 Min Li,1 Qianqian Yang3 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215123, People’s Republic of ...
Jin Z +7 more
doaj +2 more sources