Results 11 to 20 of about 210,811 (163)

Pregnenolone and pregnenolone sulfate metabolism by human fetal testes in vitro [PDF]

, 1970
Homogenates of testes from human fetuses of 12-16 weeks gestation were incubated in vitro with pregnenolone-4-14C and pregnenolone-7-3H-sulfate. Dehydroepiandrosterone sulfate and pregnenediol sulfate, each bearing the tritium label only, were identified
Jaffe, Robert B., Perez-Palacios, Gregorio, Lamont, Kenneth G., Perez, Ana E.   +3 more
core   +7 more sources

The role of genetic polymorphisms in the sulfation of pregnenolone by human cytosolic sulfotransferase SULT2B1a

Scientific Reports
Pregnenolone is a key intermediate in the biosynthesis of many steroid hormones and neuroprotective steroids. Sulfotransferase family cytosolic 2B member 1 (SULT2B1a) has been reported to be highly selective to sulfate pregnenolone.
Eid Alatwi, Ahsan F. Bairam
doaj   +2 more sources

Altered TRPM3-Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post-COVID-19 Condition Patients. [PDF]

Eur J Immunol
Immunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post‐COVID‐19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3‐mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC ...
Magawa CT, Eaton-Fitch N, Muraki K, Marshall-Gradisnik S.   +3 more
europepmc   +2 more sources

Human Microglia Synthesize Neurosteroids to Cope with Rotenone-Induced Oxidative Stress

Antioxidants, 2023
We obtained evidence that mouse BV2 microglia synthesize neurosteroids dynamically to modify neurosteroid levels in response to oxidative damage caused by rotenone.
Chiara Lucchi, Alessandro Codeluppi, Monica Filaferro, Giovanni Vitale, Cecilia Rustichelli, Rossella Avallone, Jessica Mandrioli, Giuseppe Biagini   +7 more
doaj   +1 more source

Identification of steroid sulfate transport processes in the human mammary gland [PDF]

, 2003
Circulating hormones and local biotransformation of steroid precursors are both sources of estrogen in human mammary tissue. Estrone-3-sulfate (E(1)S) is an important estrogenic form in premenopausal women, and dehydroepiandrosterone sulfate (DHEAS ...
Pizzagalli, F., Meier, P. J., Varga, Z., Huber, R. D., Folkers, G., St-Pierre, M. V.   +5 more
core   +1 more source

Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients

Molecular Medicine, 2019
Background Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a complex multifactorial disorder of unknown cause having multi-system manifestations.
H. Cabanas, K. Muraki, C. Balinas, N. Eaton-Fitch, D. Staines, S. Marshall-Gradisnik   +5 more
doaj   +1 more source

Simultaneous quantification of cholesterol sulfate, androgen sulfates, and progestagen sulfates in human serum by LC-MS/MS[S]

Journal of Lipid Research, 2015
Steroids are primarily present in human fluids in their sulfated forms. Profiling of these compounds is important from both diagnostic and physiological points of view.
Alberto Sánchez-Guijo, Vinzenz Oji, Michaela F. Hartmann, Heiko Traupe, Stefan A. Wudy   +4 more
doaj   +1 more source

Migraine-relevant sex-dependent activation of mouse meningeal afferents by TRPM3 agonists

The Journal of Headache and Pain, 2022
Background Migraine is a common brain disorder that predominantly affects women. Migraine pain seems mediated by the activation of mechanosensitive channels in meningeal afferents.
G. Krivoshein, E. A. Tolner, van den Maagdenberg AMJM, R. A. Giniatullin   +3 more
doaj   +1 more source

TRPM3 in Brain (Patho)Physiology

Frontiers in Cell and Developmental Biology, 2021
Already for centuries, humankind is driven to understand the physiological and pathological mechanisms that occur in our brains. Today, we know that ion channels play an essential role in the regulation of neural processes and control many functions of ...
Katharina Held, Katharina Held, Balázs István Tóth   +2 more
doaj   +1 more source

Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain

Journal of Lipid Research, 2004
A new sample preparation method coupled to GC-MS analysis was developed and validated for quantification of sulfate esters of pregnenolone (PREG-S) and dehydroepiandrosterone (DHEA-S) in rat brain.
Philippe Liere, Antoine Pianos, Bernard Eychenne, Annie Cambourg, Suya Liu, William Griffiths, Michael Schumacher, Jan Sjövall, Etienne-Emile Baulieu   +8 more
doaj   +1 more source