Erratum: Alkhatib et al., "Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits". [PDF]
J Neurosci, 2020 europepmc +4 more sources
Transient Receptor Potential Melastatin 3 Channel [PDF]
Biophysical Journal, 2011 Transient receptor potential (TRP) channels are a large family of ion channel proteins, that are activated and regulated through strikingly diverse mechanisms, making them suitable candidates for cellular sensors.TRPM3 is based on sequence homology most closely related to TRPM1.
Vriens, Joris, Voets, Thomas
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Expression and Characterization of Human Transient Receptor Potential Melastatin 3 (hTRPM3) [PDF]
Journal of Biological Chemistry, 2003 Transient receptor potential (TRP) cation-selective channels are an emerging class of proteins that are involved in a variety of important biological functions including pain transduction, thermosensation, mechanoregulation, and vasorelaxation. Utilizing a bioinformatics approach, we have identified the full-length human TRPM3 (hTRPM3) as a member of ...
Ning, Lee +11 more
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Cellular Regulation of Transient Receptor Potential Melastatin 3 (TRPM3) Channel Activity [PDF]
Biophysical Journal, 2014 TRPM3 is a less characterized member of the melastatin subfamily of transient receptor potential (TRP) ion channels activated by the neurosteroid pregnenolone sulphate (PS) and heat. Recently we have shown that TRPM3 is a thermosensitive nociceptor channel involved in the detection of noxious heat and mediating the nocifensive behaviour evoked by PS ...
Toth, Balazs I. +3 more
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Renin-Angiotensin Signaling and Vascular Function: Insights into Health and Disease. [PDF]
Acta Physiol (Oxf)ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Bertoldi G, Sonkusare SK.
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TRPM3 in Brain (Patho)Physiology
Frontiers in Cell and Developmental Biology, 2021 Already for centuries, humankind is driven to understand the physiological and pathological mechanisms that occur in our brains. Today, we know that ion channels play an essential role in the regulation of neural processes and control many functions of ...
Katharina Held +2 more
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Correction: Uric acid promotes myocardial infarction injury via activating Pyrin domain-containing 3 inflammasome and reactive oxygen species/transient receptor potential melastatin 2/Ca2 + pathway [PDF]
BMC Cardiovascular DisordersHaiyun Wu +3 more
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Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels. [PDF]
J Biol Chem, 2012 TRPM3 channels form ionotropic steroid receptors in the plasma membrane of pancreatic β and dorsal root ganglion cells and link steroid hormone signaling to insulin release and pain perception, respectively. We identified and compared the function of a number of TRPM3 splice variants present in mouse, rat and human tissues.
Frühwald J +8 more
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Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. [PDF]
J Dent Res, 2015 Bone remodeling occurs in response to various types of mechanical stress. The periodontal ligament (PDL) plays an important role in mechanical stress–mediated alveolar bone remodeling. However, the underlying mechanism at the cellular level has not been extensively studied.
Son GY +4 more
europepmc +5 more sources
Biological and Pharmaceutical Bulletin, 2021 Oligodendrocyte precursor cells (OPCs) are glial cells that differentiate into oligodendrocytes and myelinate axons. The number of OPCs is reportedly increased in brain lesions in some demyelinating diseases and during ischemia; however, these cells also secrete cytokines and elicit both protective and deleterious effects in response to brain injury ...
Ohashi, Kana +6 more
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