Results 31 to 40 of about 6,388 (148)

Modulation of Transient receptor potential melastatin 3 by protons through its intracellular binding sites [PDF]

, 2020
Abstract Transient receptor potential melastatin 3 channel (TRPM3) is a calcium-permeable nonselective cation channel that plays an important role in modulating glucose homeostasis in the pancreatic beta cells. However, how TRPM3 is regulated under physiological and pathological conditions is poorly understood.
Md Zubayer Hossain Saad, Liuruimin Xiang, Yan-Shin Liao, Leah R. Reznikov, Jianyang Du   +4 more
openaire   +1 more source

Volatile anaesthetics inhibit the thermosensitive nociceptor ion channel transient receptor potential melastatin 3 (TRPM3)

Biochemical Pharmacology, 2020
Volatile anaesthetics (VAs) are the most widely used compounds to induce reversible loss of consciousness and maintain general anaesthesia during surgical interventions. Although the mechanism of their action is not yet fully understood, it is generally believed, that VAs depress central nervous system functions mainly through modulation of ion ...
Kelemen, Balazs, Lisztes, Erika, Vladar, Anita, Hanyicska, Martin, Almassy, Janos, Olah, Attila, Szollosi, Attila Gabor, Penzes, Zsofia, Posta, Janos, Voets, Thomas, Biro, Tamas, Toth, Balazs Istvan   +11 more
openaire   +3 more sources

Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients

Journal of Translational Medicine, 2022
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the pathomechanism of ME/CFS remains elusive, reduced natural killer (NK) cell cytotoxic function is a consistent immunological ...
Natalie Eaton-Fitch, Stanley Du Preez, Hélène Cabanas, Katsuhiko Muraki, Donald Staines, Sonya Marshall-Gradisnik   +5 more
doaj   +1 more source

Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels. [PDF]

Clin Exp Immunol, 2017
Summary Transient receptor potential melastatin subfamily 3 (TRPM3) ion channels play a role in calcium (Ca2+) cell signalling. Reduced TRPM3 protein expression has been identified in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) patients.
Nguyen T, Johnston S, Clarke L, Smith P, Staines D, Marshall-Gradisnik S.   +5 more
europepmc   +5 more sources

The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients

Journal of Translational Medicine, 2021
Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious multifactorial disorder. The origin remains ambiguous, however reduced natural killer (NK) cell cytotoxicity is a consistent immunological feature of ME/CFS.
Natalie Eaton-Fitch, Hélène Cabanas, Stanley du Preez, Donald Staines, Sonya Marshall-Gradisnik   +4 more
doaj   +1 more source

TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells

Frontiers in Pharmacology, 2018
In human uveal melanoma (UM), tumor enlargement is associated with increases in aqueous humor vascular endothelial growth factor-A (VEGF-A) content that induce neovascularization.
Lia Walcher, Clara Budde, Arina Böhm, Peter S. Reinach, Priyavathi Dhandapani, Nina Ljubojevic, Markus W. Schweiger, Henriette von der Waydbrink, Ilka Reimers, Josef Köhrle, Stefan Mergler   +10 more
doaj   +1 more source

Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms

eLife, 2020
Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca2+ permeable non-selective cation channel activated by heat and chemical agonists such as pregnenolone sulfate and CIM0216.
Siyuan Zhao, Yevgen Yudin, Tibor Rohacs
doaj   +1 more source

The LCK-14-3-3ζ-TRPM8 axis regulates TRPM8 function/assembly and promotes pancreatic cancer malignancy

Cell Death and Disease, 2022
Transient receptor potential melastatin 8 (TRPM8) functions as a Ca2+-permeable channel in the plasma membrane (PM). Dysfunction of TRPM8 is associated with human pancreatic cancer and several other diseases in clinical patients, but the underlying ...
Yuan Huang, Shi Li, Qinfeng Liu, Zhijie Wang, Shunyao Li, Lei Liu, Weiwei Zhao, Kai Wang, Rui Zhang, Longfei Wang, Ming Wang, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang   +15 more
doaj   +1 more source

Transient Receptor Potential Melastatin 3 and Intracellular Calcium in Natural Killer Cells in Multiple Sclerosis

International Journal of Clinical Medicine, 2018
Background: Natural killer (NK) cell phenotypes have reported to be implicated in the pathomechanism of Multiple Sclerosis (MS). Several investigators have observed reduced peripheral numbers, reduced cytotoxic activity, and altered CD56Dim and CD56Bright NK cell phenotypes.
Clarke, Laura, Broadley, Simon, Nguyen, Thao, Johnston, Samantha, Eaton, Natalie, Staines, Donald, Marshall-Gradisnik, Sonya   +6 more
openaire   +3 more sources

CREB, AP-1, ternary complex factors and MAP kinases connect transient receptor potential melastatin-3 (TRPM3) channel stimulation with increased c-Fos expression. [PDF]

Br J Pharmacol, 2016
Background and PurposeThe rise in intracellular Ca2+ stimulates the expression of the transcription factor c‐Fos. Depending on the mode of entry of Ca2+ into the cytosol, distinct signal transducers and transcription factors are required. Here, we have analysed the signalling pathway connecting a Ca2+ influx via activation of transient receptor ...
Rubil S, Rössler OG, Thiel G.
europepmc   +4 more sources