Results 51 to 60 of about 6,388 (148)

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Oral Lesions and Dental Status in Individuals Using Oral Tobacco‐Free Nicotine Pouches

Oral Diseases, EarlyView.
ABSTRACT Objectives Users of Swedish nicotine pouches and traditional oral tobacco‐derived pouches were compared to non‐users for clinical tissue responses and oral health status. In addition, the habits associated with snus use were also evaluated. Material and Methods In this cross‐sectional study, participants aged 18–30 were recruited from nine ...
Masoumeh Daneshian, Lars Fredriksson, Pia Skott, Karin Garming Legert   +3 more
wiley   +1 more source

Decoding Cold Therapy Mechanisms of Enhanced Bone Repair through Sensory Receptors and Molecular Pathways

Biomedicines
Applying cold to a bone injury can aid healing, though its mechanisms are complex. This study investigates how cold therapy impacts bone repair to optimize healing.
Matthew Zakaria, Justin Matta, Yazan Honjol, Drew Schupbach, Fackson Mwale, Edward Harvey, Geraldine Merle   +6 more
doaj   +1 more source

AMTB, a TRPM8 antagonist, suppresses growth and metastasis of osteosarcoma through repressing the TGFβ signaling pathway

Cell Death and Disease, 2022
Since its first identification in prostate cancers and prostate tissues, transient receptor potential melastatin-subfamily member 8 (TRPM8) is subsequently found to be overexpressed in a wide range of cancers and is shown to be implicated in ...
Yujie Liu, Ao Leng, Lin Li, Bo Yang, Shihui Shen, Hui Chen, Enhao Zhu, Qiyue Xu, Xiaoyu Ma, Peilin Shi, Yun Liu, Tielong Liu, Lei Li, Kun Li, Dan Zhang, Jianru Xiao   +15 more
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Influence of facial cooling on carotid body tonic activity and sensitivity

Experimental Physiology, EarlyView.
Abstract Facial cooling can increase ventilation and augment the hypoxic ventilatory response. Whole body cooling increases both carotid body tonic activity and sensitivity; however, whether isolated facial cooling induces similar carotid body hyperexcitability was unknown.
Robyn Morley, Liam D. Corr, Elliott J. Jenkins, Joseph A. Killick, Travis D. Gibbons, Joshua C. Tremblay   +5 more
wiley   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat

The EMBO Journal
Copine-6 is a calcium-sensitive phospholipid-binding protein of the evolutionarily conserved Copine family. In the central nervous system, Copine-6 regulates function of some neurotransmitter receptors and structural plasticity of dendritic spines ...
Yiting Gao, Shengxiang Yan, Zhongyang Zhang, Jieyao Zhang, Meng Yang, Shihab Shah, Sofia Figoli, Qi Jing, Haixia Gao, Nikita Gamper   +9 more
doaj   +1 more source

Migraine-relevant sex-dependent activation of mouse meningeal afferents by TRPM3 agonists

The Journal of Headache and Pain, 2022
Background Migraine is a common brain disorder that predominantly affects women. Migraine pain seems mediated by the activation of mechanosensitive channels in meningeal afferents.
G. Krivoshein, E. A. Tolner, van den Maagdenberg AMJM, R. A. Giniatullin   +3 more
doaj   +1 more source