Results 61 to 70 of about 6,388 (148)

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

eLife, 2018
Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel required for immune cell activation, insulin secretion, and body heat control.
Zhe Zhang, Balázs Tóth, Andras Szollosi, Jue Chen, László Csanády   +4 more
doaj   +1 more source

Borneol Is a TRPM8 Agonist that Increases Ocular Surface Wetness. [PDF]

PLoS ONE, 2016
Borneol is a compound widely used in ophthalmic preparations in China. Little is known about its exact role in treating eye diseases. Here we report that transient receptor potential melastatin 8 (TRPM8) channel is a pharmacological target of borneol and
Gui-Lan Chen, Ming Lei, Lu-Ping Zhou, Bo Zeng, Fangdong Zou   +4 more
doaj   +1 more source

Additional file 1 of Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients

, 2022
Additional file 1: Fig. S1. Natural Killer Cell Purity. NK cells purity (CD3−CD56+) was 93.90% ± 1.054 for post COVID-19 condition, 93.22% ± 3.098 for HC and 93.64% ± 1.521 for ME/CFS patients as determined by flow cytometry. NK cells were incubated for 20 min at room temperature in the presence of CD56 APC (0.25 μg/20 μl) and CD3 PE Cy7 (0.25 μg/5 μl)
Sasso, Etianne Martini, Muraki, Katsuhiko, Eaton-Fitch, Natalie, Smith, Peter, Lesslar, Olivia Ly, Deed, Gary, Marshall-Gradisnik, Sonya   +6 more
openaire   +1 more source

Ca2+-independent cytotoxicity of menthol in the A549 lung cancer cell line

Current Research in Toxicology
Menthol evokes cooling sensations by activating the transient receptor potential melastatin 8 (TRPM8) channel, resulting in relaxing, anti-inflammatory, and analgesic effects when administered through inhalation and topical application.
Kenji Takahashi, Toshio Ohta
doaj   +1 more source

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

In silico investigation of the association of the TRPM8 ion channel with the pungent flavor of Chinese herbs

Journal of Traditional Chinese Medical Sciences, 2016
Objective: Explicating the property and action of traditional Chinese medicine (TCM) in the perspectives of modern science deepens the insight into the property of TCM, and provides the basis for new drug discovery and clinical therapy. In this study, we
Yuxin Zhang, Xing Wang, Shifeng Wang, Qiao Zhang, Sha Peng, Xi Li, Yanling Zhang, Yanjiang Qiao   +7 more
doaj   +1 more source

The TRPM2–PARP‐1 Axis Involvement in Bisphenol A and Nonylphenol‐Induced Ferroptosis in Trigeminal Ganglion Cells

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3660-3674, October 2026.
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Betül Yazğan, Musa Tatar, Yener Yazğan, Kıymet Kübra Tüfekci   +3 more
wiley   +1 more source

Low‐Dose naltrexone restored TRPM3 ion channel function in natural killer cells from long COVID patients

Frontiers in Molecular Biosciences
IntroductionLong COVID is a multisystemic condition that includes neurocognitive, immunological, gastrointestinal, and cardiovascular manifestations, independent of the severity or duration of the acute SARS-CoV-2 infection.
Etianne Martini Sasso, Etianne Martini Sasso, Etianne Martini Sasso, Natalie Eaton-Fitch, Natalie Eaton-Fitch, Peter Smith, Peter Smith, Katsuhiko Muraki, Katsuhiko Muraki, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik   +10 more
doaj   +1 more source