Results 81 to 90 of about 6,388 (148)

Pro-inflammatory mediators sensitise transient receptor potential melastatin 3 cation channel (TRPM3) function in mouse sensory neurons

Neuropharmacology
Pro-inflammatory mediators can directly activate pain-sensing neurons, known as nociceptors. Additionally, these mediators can sensitise ion channels and receptors expressed by these cells through transcriptional and post-translational modulation, leading to nociceptor hypersensitivity.
Aguilera-Lizarraga, Javier, Lim, Tony K, Pattison, Luke A, Paine, Luke W, Bulmer, David C, Smith, Ewan St John   +5 more
openaire   +2 more sources

Rational tuning of temperature sensitivity of the TRPM8 channel

EMBO Reports
Detecting temperature is crucial for the survival of living organisms. Although the temperature sensitive Transient Receptor Potential Melastatin 8 (TRPM8) channel has been identified as the prototypical cold sensor, the mechanisms by which it detects ...
Lizhen Xu, Xiao Liang, Yunfei Wang, Han Wen, Wenxuan Zhen, Zhangzhi Xue, Fangfei Zhang, Xiao Yi, Xiaoying Chen, Lidan Hu, Bei Li, Bing Zhang, Zhenfeng Deng, Wei Yang, Shilong Yang, Tiannan Guo, Yi Zhu, Fan Yang   +17 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone

Journal of Translational Medicine
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with a broad overlap of symptomatology with Post-COVID Syndrome (PCS).
Matthias Löhn, Klaus Josef Wirth
doaj   +1 more source

Stimulus–Transcription Coupling of TRPM3 Channels: A Signaling Pathway from the Plasma Membrane to the Nucleus

Biomolecules
Transient receptor potential melastatin-3 (TRPM3) channels are cation channels activated by heat and chemical ligands. TRPM3 regulates heat sensation, secretion, neurotransmitter release, iris constriction, and tumor promotion.
Gerald Thiel, Oliver G. Rössler
doaj   +1 more source

Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3

Nature Communications
The transient receptor potential melastatin 3 (TRPM3) channel is a key mediator of peripheral pain signaling, and pathogenic mutations in TRPM3 are linked to neurodevelopmental delay and epilepsy.
Bahar Bazeli, Alexander V. Shkumatov, Stephan Schenck, Jean-Christophe Vanherck, Annelies Janssens, Stéphane A. H. Spieser, Damien Marchand, Robbe Roelens, Patrick Chaltin, Arnaud Marchand, Joris Vriens, Thomas Voets, Janine D. Brunner   +12 more
doaj   +1 more source

Additional file 3: of Identification and characterisation of transient receptor potential melastatin 2 and CD38 channels on natural killer cells using the novel application of flow cytometry

, 2019
Gating strategy for the analysis of TRPM2 and CD38 surface expression on NK subsets using a fluorescence minus one control at 2â h/1â h. (PDF 42 kb)
Balinas, Cassandra, Cabanas, Helene, Staines, Donald, Marshall-Gradisnik, Sonya   +3 more
openaire   +1 more source

A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3

Communications Chemistry
Transient Receptor Potential Melastatin 3 (TRPM3) is a non-selective, Ca2+-permeable ion channel that plays a pivotal role in peripheral thermosensation and nociception.
Katharina Held, Evelien Van Hoeymissen, Ilhem Dallali, Eleonora Persoons, Bahar Bazeli, Robbe Roelens, Stijn Robben, Caroline Wuyts, Marie Mulier, Silvia Pinto, Annelies Janssens, Thomas Voets, Joris Vriens   +12 more
doaj   +1 more source

Assessing the Role of the Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channel in Visceral Sensation

Abdominal pain is a significant clinical problem impacting many individuals including patients with inflammatory bowel disease (IBD). Current therapeutics for IBD-related pain include opioids which are addictive and associated with increased mortality in IBD patients.
openaire   +1 more source

Transient Receptor Potential Melastatin 3 ion channel expressed in sensory neurons mediates osteoarthritis pain in mice:TRPM3 mediates osteoarthritis pain

Objective: Osteoarthritis (OA) is a degenerative joint disease characterized by chronic pain. We investigated whether the ion channel transient receptor potential melastatin 3 (TRPM3), expressed in sensory neurons, mediates OA pain. Design: We used genetically modified mice, pharmacological tools, and behavioural assessments to evaluate the role of ...
da Costa, Robson, Pereira, Suelen, Gentry, Clive; id_orcid 0000-0002-1148-8203, Dias, Fabiana, de Lima Almeida, Bianca, Maurer, Margot, Primicheru, Laura, Moreira, Lio, Mannebach, Stefanie, Weissgerber, Petra, Philipp, Stephan, Andersson, David; id_orcid 0000-0001-7451-8548, Bevan, Stuart; id_orcid 0000-0002-8977-1797   +12 more
openaire   +1 more source