Results 71 to 80 of about 6,388 (148)

Small Leucine‐Rich Proteoglycans in Cancer: Three Decades of Discovery

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT Small leucine‐rich proteoglycans (SLRPs) are a well‐known family of extracellular matrix (ECM) molecules. They consist of five classes with 18 different protein cores originally recognized as having a physically supportive component to the extracellular structure and tissue integrity.
Gabriel J. Pascal, Sadie Kim, Christopher Xie, Maria Danial, Iris Barone, Renato V. Iozzo   +5 more
wiley   +1 more source

Nuclear paraspeckle assembly transcript 1 promotes photophobia behavior in mice via miR-196a-5p/Trpm3 coupling

The Journal of Headache and Pain
Background The long noncoding RNA, NEAT1, is recognized as a key regulator of proinflammatory gene expression; Yet, its functional role in migraine remains unexplored, despite the central role of neuroinflammatory mechanisms in migraine pathophysiology ...
Zhuoan Huang, Xingshen Li, Xiaolin Wang, Jiaqi Wu, Ziyang Gong, Sulev Kõks, Minyan Wang   +6 more
doaj   +1 more source

Herbal Extracts and Plant‐Derived Bioactives in Atopic Dermatitis: Evidence, Mechanisms, Pediatric Safety, and Translational Priorities

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Food‐derived bioactives, herbal extracts, and standardized botanical products are being investigated as adjunctive strategies for atopic dermatitis. Their biological activity is shaped not only by plant source and nominal dose, but also by fermentation, drying, heating, extraction, food‐matrix binding, gastrointestinal transformation, and formulation ...
Muhuang Zeng, Qianlan Yuan, Shuojia Huang, Xiaofei Lu   +3 more
wiley   +1 more source

ATP release mediated by TRPM3 enhances invasion in glioblastoma

Animal Cells and Systems
Glioblastoma (GBM) is the most aggressive and lethal form of primary brain tumor, characterized by uncontrolled proliferation and invasion into surrounding brain tissue.
Kkot Garam Bae, Chae Won Song, Jae Hong Yoo, Myunghoon Lee, Noah Koo, Gangsan Lee, Yongmin Mason Park, Jihwan Yoo, In-Young Hwang, Dong Ho Woo, C. Justin Lee, Kyung-Seok Han   +11 more
doaj   +1 more source

Topical neurokinin-1 receptor antagonism ameliorates ocular pain and prevents corneal nerve degeneration in an animal model of dry eye disease

PAIN Reports
. Introduction:. Ocular pain is a common complaint to eye care providers, associated with a variety of ocular conditions, among which dry eye disease (DED) is affecting millions of people worldwide.
Amirreza Naderi, Yukako Taketani, Shudan Wang, Francesca Kahale, Ann Yung, Pier Luigi Surico, Yihe Chen, Reza Dana   +7 more
doaj   +1 more source

Effects of Ulmi Pumilae Cortex on AGS Gastric Cancer Cells

Journal of Pharmacopuncture, 2013
Objective: Ulmi Pumilae Cortex (UPC) is a deciduous tree with uneven pinnate leaves and is classified as a subfamily of Ulmuceae and contains many pharmacologically active constituents.
Lim Bora , Lee Hee Jung , Kim Min Chul , Kim Byung Joo   +3 more
doaj   +1 more source

Ginsenoside Rd and ischemic stroke; a short review of literatures

Journal of Ginseng Research, 2015
Panax ginseng is a well-known economic medical plant that is widely used in Chinese traditional medicine. This species contains a unique class of natural products—ginsenosides.
Seyed Fazel Nabavi, Antoni Sureda, Solomon Habtemariam, Seyed Mohammad Nabavi   +3 more
doaj   +1 more source

Inorganic polyphosphate modulates TRPM8 channels.

PLoS ONE, 2009
Polyphosphate (polyP) is an inorganic polymer built of tens to hundreds of phosphates, linked by high-energy phosphoanhydride bonds. PolyP forms complexes and modulates activities of many proteins including ion channels.
Eleonora Zakharian, Baskaran Thyagarajan, Robert J French, Evgeny Pavlov, Tibor Rohacs   +4 more
doaj   +1 more source

Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Frontiers in Medicine
IntroductionMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic disease hallmarked by multiple systemic symptoms, such as neurocognitive, respiratory, immunological, gastrointestinal, and cardiovascular impairment, which worsen ...
Etianne Martini Sasso, Etianne Martini Sasso, Teagan S. Er, Natalie Eaton-Fitch, Natalie Eaton-Fitch, Livia Hool, Livia Hool, Katsuhiko Muraki, Katsuhiko Muraki, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik   +10 more
doaj   +1 more source

TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan

BMC Musculoskeletal Disorders, 2010
Background Calcium-permeable channels are known to have roles in many mammalian cell types but the expression and contribution of such ion channels in synovial cells is mostly unknown.
English Anne A, Sukumar Piruthivi, Naylor Jacqueline, Majeed Yasser, Ciurtin Coziana, Emery Paul, Beech David J   +6 more
doaj   +1 more source