Results 191 to 200 of about 447,569 (400)

Da-Chuan-Xiong Decoction Ameliorates Sodium Sensitivity and Plasma Norepinephrine via Attenuation of Brain Oxidative Stress in the DOCA-Salt Hypertensive Rats

International Journal of Hypertension
Background. Da-Chuan-Xiong Decoction (DCXD) is an aqueous extract from a classic Chinese herbal formula composed of dried rhizomes of Ligusticum chuanxiong Hort and Gastrodia elata Bl. in the mass ratio of 4 : 1.
Qi Zhang, Hao Li, Shan Zhao, Fangfang Li, Yingying Tan   +4 more
doaj   +1 more source

Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.

New England Journal of Medicine, 2005
S. Shankaran, A. Laptook, R. Ehrenkranz, J. Tyson, S. McDonald, E. Donovan, A. Fanaroff, W. Poole, L. Wright, R. Higgins, N. Finer, W. Carlo, S. Duara, W. Oh, C. M. Cotton, D. Stevenson, B. Stoll, J. Lemons, R. Guillet, A. Jobe   +19 more
semanticscholar   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

A case of sudden posterior reversible encephalopathy syndrome (PRES) in a 32 year old with a twin pregnancy [PDF]

, 2016
Maria Agius, Nicholas Felice, Maria Mallia, Yves Muscat Baron   +3 more
openalex   +1 more source

The impact of social relationships on the risk of stroke and post-stroke mortality: a systematic review and meta-analysis

BMC Public Health
Background The association between poor social relationships and post-stroke mortality remains uncertain, and the evidence regarding the relationship between poor social relationships and the risk of stroke is inconsistent.
Mingxian Meng, Zheng Ma, Hangning Zhou, Yanming Xie, Rui Lan, Shirui Zhu, Deyu Miao, Xiaoming Shen   +7 more
doaj   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Evolution of transmissible spongiform encephalopathy and the prion protein gene (PRNP) in mammals [PDF]

, 2020
Brittaney L. Buchanan, Robert M. Zink
openalex   +1 more source

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury

Journal of Neuropathology and Experimental Neurology, 2009
A. Mckee, R. Cantu, Christopher J. Nowinski, E. Hedley‐Whyte, B. Gavett, A. Budson, Veronica E. Santini, Hyo-Soon Lee, Caroline A. Kubilus, R. Stern   +9 more
semanticscholar   +1 more source

Hepatic Encephalopathy [PDF]

Journal of Clinical and Experimental Hepatology, 2015
openaire   +2 more sources

Commentary: Three questions for the study of traumatic brain injury in animals

The Anatomical Record, EarlyView.
Gregory Hollin
wiley   +1 more source