Results 211 to 220 of about 235,104 (268)

Renally Generated Ammonia as a Cause of Hyperammonaemic Non-Hepatic Encephalopathy. [PDF]

Nephrology (Carlton)
Nkunu VE, Mak KYL, Dodia K, Morales FD, Chan AKJ, Alexander RT, Hwang PM.   +6 more
europepmc   +1 more source

Kv3.1 activation suppresses provoked and spontaneous seizures in a mouse Dravet syndrome model

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acidergic (GABAergic) parvalbumin‐positive (PV+) interneurons are critical for maintaining cortical inhibitory tone, with their dysfunction predictably leading to epilepsy. Rapid PV+ interneuron firing is essential for their normal function and is maintained in part by potassium voltage‐gated channels.
Sheryl Anne D. Vermudez, Mustafa Q. Hameed, Yongho Choe, Gabrielle E. McGinty, Amanda M. Liebhardt, Rui Lin, Benjamin Hui, Yini Liang, David J. Arce, Henry H. C. Lee, Mustafa Sahin, Alexander Rotenberg   +11 more
wiley   +1 more source

Adeno‐associated virus‐mediated restoration of NaV1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of NaV1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden ...
Martina Mainardi, Simone Brusco, Serena Gea Giannelli, Vania Broccoli, Gaia Colasante   +4 more
wiley   +1 more source

From targeted SCN1A analysis to whole exome sequencing: clinical utility and novel genetic findings in a Hungarian paediatric epilepsy cohort. [PDF]

Hum Genet
Szalai R, Till A, Galimurka K, Banfai Z, Zsigmond A, Hadzsiev K.   +5 more
europepmc   +1 more source

Non‐contrast MRI reliably captures perfusion abnormalities in status epilepticus

Epilepsia, EarlyView.
Abstract Objective To determine whether non‐contrast pseudo‐continuous arterial spin labeling (pCASL) detects status epilepticus (SE)–related perfusion abnormalities and shows quantitative correspondence with dynamic susceptibility contrast (DSC) perfusion magnetic resonance imaging (MRI), and to compare single‐slice and volumetric approaches for ...
Lukas Machegger, Pilar Bosque‐Varela, Jürgen Steinbacher, Johannes Pfaff, Eugen Trinka, Giorgi Kuchukhidze   +5 more
wiley   +1 more source

Establishing consensus diagnostic criteria for ring chromosome 20 syndrome: A modified electronic Delphi consensus study

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to establish expert consensus clinical and diagnostic criteria for ring chromosome 20 syndrome using a modified electronic Delphi process. Methods In this modified two‐round electronic Delphi consensus study, international experts rated candidate statements using a 9‐point Likert scale.
Abizairie Sánchez‐Feliciano, William D. James, Mark P. Fitzgerald, Allison Watson, Angela Peron, Antonio Gil‐Nagel, Kenneth A. Myers, Kentaro Tokumoto, Lieven Lagae, Nancy B. Spinner, Rhys H. Thomas, Rudolf R. Roth, Sarah Woodson, Tim Buckinx, Yushi Inoue, John S. Barbieri   +15 more
wiley   +1 more source

Metronidazole-Induced Neurotoxicity After Twenty Years of Exposure: Resolution Following Drug Withdrawal. [PDF]

Clin Case Rep
Biswas HK, Marzuqah S, Sultana S, Biswas R.   +3 more
europepmc   +1 more source

Fenfluramine treatment and seizure‐free days in pediatric and adult patients with Lennox–Gastaut syndrome: A post hoc analysis

Epilepsia, EarlyView.
This graphical abstract provides an overview of the post hoc analysis evaluating change in percentage of seizure‐free days in pediatric and adult patients treated with fenfluramine in the Lennox‐Gastaut syndrome phase 3 study. Abstract The most common primary endpoint for assessing treatment efficacy in patients with Lennox–Gastaut syndrome (LGS) is ...
Stéphane Auvin, Ingrid E. Scheffer, Antonio Gil‐Nagel, Patrick Healy, Amélie Lothe, Mélanie Langlois, Jayne Abraham, Lieven Lagae, Kelly G. Knupp   +8 more
wiley   +1 more source

ChatGPT-4o in delirium recognition: a pilot study. [PDF]

Rev Assoc Med Bras (1992)
Alpay KC, Avci S, Gunduz A, Ozata D, Avlagı GK, Bilgin S, Durak U, Doventas A, Erdincler DS.   +8 more
europepmc   +1 more source