Results 231 to 240 of about 453,156 (401)

L‐Relationship between uncertainty and average seizure frequency in clinical trials of antiseizure medications

open access: yesEpilepsia, EarlyView.
Abstract Objective Antiseizure medications are approved based on clinical trials that demonstrate their efficacy as measured by reductions in seizure frequency (SF). When designing these trials, trialists must select inclusion criteria where SF can be reliably measured to maintain statistical power.
Wesley T. Kerr   +6 more
wiley   +1 more source

Toxic Encephalopathy [PDF]

open access: yesJournal of General Internal Medicine, 2012
Abhishek, Agarwal, Tobias, Vancil
openaire   +2 more sources

Memantine treatment in individuals with GRIN gain‐of‐function variants is associated with improvements in behavior, development, and seizure frequency

open access: yesEpilepsia, EarlyView.
Abstract Objective GRIN‐related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N‐methyl‐D‐aspartate receptor (NMDAR) function. Functional changes include gain (GoF) and loss of receptor function (LoF). Clinical reports describing the use of the NMDAR blocker memantine in GRIN‐related disorders
Maike Karnstedt   +17 more
wiley   +1 more source

Baseline characteristics and feasibility of clinical outcome measures in CDKL5 deficiency disorder: The CANDID observational study

open access: yesEpilepsia, EarlyView.
Abstract Objective CDKL5 deficiency disorder (CDD) is a rare X‐linked developmental and epileptic encephalopathy caused by loss‐of‐function variants in the CDKL5 gene. Preclinical experiments using enzyme replacement or gene therapies show promise and could be transformative therapies.
Xavier Liogier d'Ardhuy   +8 more
wiley   +1 more source

Moderate hypothermia to treat perinatal asphyxial encephalopathy.

open access: yesNew England Journal of Medicine, 2009
D. Azzopardi   +12 more
semanticscholar   +1 more source

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