Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie [PDF]
With increased awareness of the diversity of transmissible spongiform encephalopathy (TSE) strains in the ruminant population, comes an appreciation of the need for improved methods of differential diagnosis. Exposure to bovine spongiform encephalopathy (
Bossers, A.+5 more
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Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]
The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
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Prognostic value of preoperatively obtained clinical and laboratory data in predicting survival following orthotopic liver transplantation [PDF]
Twenty‐seven clinical and laboratory data and the subsequent clinical course of 93 consecutive adult patients who underwent orthotopic liver transplantation for various chronic advanced liver diseases were analyzed retrospectively to assess the risk ...
Child+13 more
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Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock [PDF]
Stress doses of hydrocortisone a re known to have immunomodulatory effects in patients with hyperdynamic septic shock. The prognosis correlates with the presence and severity of septic encephalopathy. However, neurological evaluation is influenced by the
Anderson+46 more
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Early changes in pro-inflammatory cytokine levels in neonates with encephalopathy are associated with remote epilepsy. [PDF]
BackgroundNeonatal seizures are associated with adverse neurologic sequelae including epilepsy in childhood. Here we aim to determine whether levels of cytokines in neonates with brain injury are associated with acute symptomatic seizures or remote ...
Barkovich, A James+6 more
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TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update [PDF]
Refractory ascites is a frequent complication of advanced cirrhosis and is associated with hepatorenal syndrome and hepatic hydrothorax. Large volume paracentesis and pleurodesis are regarded as first-line treatments in patients who do not respond ...
Gerbes, Alexander L., Roessle, Martin
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The utility of scoring systems in critically ill cirrhotic patients admitted to a general intensive care unit [PDF]
Purpose: This study aimed to establish which prognostic scoring tool provides the greatest discriminative ability when assessing critically ill cirrhotic patients in a general intensive care unit (ICU) setting.<p></p> Methods: This was a 12-
Emerson, Philip+7 more
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Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury [PDF]
Objective: Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been linked with increased risk of long-term neurodegenerative changes, specifically chronic traumatic encephalopathy (CTE).
Acker, Christopher M.+11 more
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TSE pathogenesis in cattle and sheep [PDF]
Many studies have been undertaken in rodents to study the pathogenesis of transmissible spongiform encephalopathies (TSE). Only a few studies have focused on the pathogenesis of bovine spongiform encephalopathy (BSE) and scrapie in their natural hosts ...
Bossers, A.+2 more
core +3 more sources
GNAO1 encephalopathy: broadening the phenotype and evaluating treatment and outcome [PDF]
OBJECTIVE: To describe better the motor phenotype, molecular genetic features, and clinical course of GNAO1-related disease. METHODS: We reviewed clinical information, video recordings, and neuroimaging of a newly identified cohort of 7 patients ...
Bianchini, C+20 more
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