Results 51 to 60 of about 2,504 (290)

Switching disease‐modifying therapies in patients with spinal muscular atrophy: A systematic review on effectiveness outcomes

British Journal of Clinical Pharmacology, EarlyView.
With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić, Elvira Meni Maria Gkrinia, Patrick Eustaquio, Andrea Katrin Faour, Dinko Vitezić   +4 more
wiley   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Optimal dosing for vascular anomalies paediatric patients with population pharmacokinetic model of sirolimus

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Sirolimus is currently used off‐label for paediatric patients with vascular anomalies. However, the optimal dosage regimen for paediatric patients remains controversial. This study aimed to determine the optimal dosing regimen of sirolimus in these patients using a population pharmacokinetic (PK) model.
Seongmee Jeong, Jungryul Kim, Woojin Jung, Jiyeon Jeon, Hyeongjun Jo, Kyoung‐Bin Ryu, Ja‐Young Hong, Kwan Soo Kim, Seongjun Yang, Hee Young Ju, Hwi‐yeol Yun, Jung‐woo Chae, Keon Hee Yoo, Soyoung Lee   +13 more
wiley   +1 more source

Enchiridion [PDF]

ENCHIRIDION Enchiridion ( - ) Cover ( - ) Titelseite ([1]r) Holzschnitt ([1]v) Vorrede ([2]r) Die Zehen Gebot/ Wie sie ein Hauß-Vater seinem Gesinde einfältiglich fürhalten sol.
Luther, Martin
core   +1 more source

Reescribiendo a Grocio. El Derecho natural innato de Diego Vincenzo Vidania

Hispania, 2015
El artículo atiende a un singular manuscrito compuesto por el jurista aragonés Diego Vincenzo Vidania en 1712 y titulado El derecho natural innato en la mente de los hombres y sus efectos.
José María Iñurritegui Rodríguez
doaj   +1 more source

COPING WITH COVID-19: URGENT NEED FOR BUILDING RESILIENCE THROUGH COGNITIVE BEHAVIOUR THERAPY

Khyber Medical University Journal, 2020
At the start of 2020, originating from Wuhan city, coronavirus disease 2019 (COVID-19) started to spread throughout China.1 The World Health Organization has declared this to be a pandemic.2 Both healthcare workers and the general public have been ...
Farooq Naeem, Muhammad Irfan, Afzal Javed   +2 more
doaj   +1 more source

What drives animal responses to high severity fire? The role of functional traits

Biological Reviews, EarlyView.
ABSTRACT Fire regimes are changing worldwide, with increases in the frequency, extent, and severity of fires posing growing risks to biodiversity. Fire severity – the degree of habitat alteration following fire – strongly influences both immediate survival and long‐term recovery of fauna.
Grace A. Vielleux, Trent D. Penman, Victoria A. Reynolds, Matthew H. Swan   +3 more
wiley   +1 more source

The Sources of the 1545 Old Prussian Language Catechisms

Acta Historica Universitatis Klaipedensis, 2017
The Teutonic Order in Prussia recognised and acknowledged its responsibility to catechise both the German-speaking colonists and the native population. The Reformation made no radical changes to these requirements, but gave them serious attention. During
Darius Petkūnas
doaj   +1 more source

Internal Marketing of Sustainability: Nonmanagerial Employees' Perspectives in the Hospitality Sector

Business Strategy and the Environment, EarlyView.
ABSTRACT Sustainable business practices are widely promoted in hospitality, yet a persistent gap persists between sustainability strategies and their implementation in daily operations. This study focuses on the sustainability strategy–implementation gap by examining how nonmanagerial employees, responsible for operational delivery, perceive and ...
Zivai Machaka Mare, Humeyra Dogru Dastan
wiley   +1 more source

Un Enquiridion de Erasmo desconocido y un raro ejemplar del Libro de Albeytería de Francisco de la Reyna adquiridos por la Biblioteca Universitaria de Zaragoza, nuevas adiciones a la tipobibliografía aragonesa del siglo XVI [PDF]

Pecia Complutense, 2011
El artículo da cuenta de la adquisición, por la Biblioteca Universitaria de Zaragoza, de dos raros impresos aragoneses del siglo XVI: un Enquiridion de Erasmo, de Jorge Coci, 1529, hasta ahora absolutamente desconocido, y el ejemplar del Tratado de ...
Moralejo Álvarez, María Remedios
doaj