Results 151 to 160 of about 1,231,329 (288)
Advanced Science, EarlyView.Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu +7 more
wiley +1 more source
Integrated network pharmacology and molecular docking reveal multi-target hepatotoxic mechanisms of Xanthii fructus. [PDF]
Medicine (Baltimore)Fu X, Xiong F, Lin X, Lin Z, Jiang X.
europepmc +1 more source
Multi‐Tissue Genetic Regulation of RNA Editing in Pigs
Advanced Science, EarlyView.This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan +21 more
wiley +1 more source
Identifying Potential Drug Targets for Membranous Nephropathy Through an Analysis of Mendelian Randomization. [PDF]
CureusSaed YA +4 more
europepmc +1 more source
Advanced Science, EarlyView.A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang +14 more
wiley +1 more source
Investigation into the antidepressant mechanism of the Guizhi-Baishao herbal pair based on network pharmacology and molecular docking. [PDF]
Medicine (Baltimore)Wen Q, Hu X, Wang X, Zu F, Zhang N.
europepmc +1 more source