Results 51 to 60 of about 253,555 (314)
Advanced Science, EarlyView.ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang +11 more
wiley +1 more source
The Unity of Science between Epistemic Inertia and Nowadays Scientific Necessity [PDF]
Memoirs of the Scientific Sections of the Romanian Academy, 2019 Today, the idea of the unity of science seems to be at odds with reality, even though science was born out of the spirit of unity. Despite this impression, we consider that unity is not just an epistemic inertia, but an internal necessity of science.
Dan Gabriel Sîmbotin
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Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Мир новой экономики, 2018 The article is dedicated to the life and work of Alexander Alexandrovich Bogdanov.Alexander A. Bogdanov was the man of the multi-faceted personality: economist, doctor, author, fiction, political activist - along with Lenin, Bogdanov was the leader of ...
BORIS ALEKSEEVICH Myasoyedov
doaj
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production
Advanced Science, EarlyView.ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du +4 more
wiley +1 more source
ALEXANDER VASILIEVICH CHAYANOV. IMMORTAL IDEAS OF A GREAT SCIENTIST
Мир новой экономики, 2018 Continuing the tradition, in the next life story the author tells about another great scientist - Alexander Vasilevich Chayanov.Complex fate awaited this scientist intellectual - he survived several arrests and deportations during which he continued to ...
BORIS ALEKSEEVICH Myasoyedov
doaj
Advanced Science, EarlyView.AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li +6 more
wiley +1 more source
Iranian Journal of Information Processing & Management, 2012 The present study was carried out with the aim of investigating factors affecting utilization of information technology by students of agriculture. A survey approach was used in this study and a questionnaire was developed to gather the data.
Masoud Rezaei, Davood Mohammadi
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