Results 61 to 70 of about 178,306 (264)

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

Geography of Voyages of Louis XI and the Count of Charolais during the Confrontation between the King and the “League of the Public Welfare”

Историко-географический журнал
The article is devoted to the events of 1465 in France, when the fate of the future political structure of the kingdom was being decided in the confrontation between the King of France Louis XI and the “League of the Public Welfare”, headed by the Count ...
А. V. Verbovskiy, E. S. Grishin
doaj   +1 more source

Thinking about death: fear or courage [PDF]

حکمت سینوی
A wise and appropriate confrontation with death has been the question and concern of many philosophical systems of thought, and various opinions have been presented about the desirability and undesirability of thinking about death and different solutions
Tayebeh Karami
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Boosting scientific literacy and learning motivation in elementary students through a contextual plant encyclopedia

Biosfer
The low level of science literacy and student motivation demands innovative, relevant, and engaging learning media. This study aims to measure the effectiveness of a contextual-based plant encyclopedia in improving science literacy and student motivation
Aprilia Cyahyani Rupilu, Ika Maryani
doaj   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

A Comparative Study of the Encyclopedia Compilation Process in the Encyclopedia World of Islam & Encyclopedia of Islam – Leiden

تحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2015
Purpose: the present paper compares two reference books the Encyclopedia World of Islam &  Encyclopedia  of Islam– Leiden  with regard to the whole process of compiling the encyclopedia, and to conduct an evaluative content analysis .
seyyed ahmad hosseinzadeh, fereshteh sepehr   +1 more
doaj  

Impossibles encyclopédies

Itinéraires, 2016
R. E. Koçu was without doubt one of the most distinguished scholars on Istanbul. He seeked to describe with the rarest details the strange habits regarding the social life of Old Istanbul within the context of Ottoman and Early Republican History.
Timour Muhidine
doaj   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source