Results 61 to 70 of about 253,555 (314)
BiosferThe low level of science literacy and student motivation demands innovative, relevant, and engaging learning media. This study aims to measure the effectiveness of a contextual-based plant encyclopedia in improving science literacy and student motivation
Aprilia Cyahyani Rupilu, Ika Maryani
doaj +1 more source
A conversation analytic perspective on Quranic verses and chapters
Studies in English Language and Education, 2018 Applying a conversation-analytic framework to Quranic verses and chapters, the current qualitative study sought to shed new lights on the opening and closing verses in The Holy Quran.
Ali Kazemi +1 more
doaj +1 more source
CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
Advanced Science, EarlyView.ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu +10 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2015 Purpose: the present paper compares two reference books the Encyclopedia World of Islam & Encyclopedia of Islam– Leiden with regard to the whole process of compiling the encyclopedia, and to conduct an evaluative content analysis .
seyyed ahmad hosseinzadeh +1 more
doaj
The attraction of the Fabaceae family encyclopedia book: Educational development research
Practice of the Science of Teaching JournalCritical thinking is one of the 4C skills students need to develop to compete in the 21st-century. Learning planning is focused not only on strategies and human resources, but also on learning resources.
Salsabila Salsabila +2 more
doaj +1 more source
Advanced Science, EarlyView.In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang +15 more
wiley +1 more source
Thinking about death: fear or courage [PDF]
حکمت سینویA wise and appropriate confrontation with death has been the question and concern of many philosophical systems of thought, and various opinions have been presented about the desirability and undesirability of thinking about death and different solutions
Tayebeh Karami
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Advanced Science, EarlyView.The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source