Results 61 to 70 of about 1,239,580 (286)
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
The Unity of Science between Epistemic Inertia and Nowadays Scientific Necessity [PDF]
Memoirs of the Scientific Sections of the Romanian Academy, 2019 Today, the idea of the unity of science seems to be at odds with reality, even though science was born out of the spirit of unity. Despite this impression, we consider that unity is not just an epistemic inertia, but an internal necessity of science.
Dan Gabriel Sîmbotin
doaj
Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
, 2010 This entry in the ACPI Encyclopedia of Philosophy provides a very brief description of the nature and history of East-West comparative ...
Kaipayil, Joseph
core
Advanced Science, EarlyView.We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim +6 more
wiley +1 more source
Мир новой экономики, 2018 The article is dedicated to the life and work of Alexander Alexandrovich Bogdanov.Alexander A. Bogdanov was the man of the multi-faceted personality: economist, doctor, author, fiction, political activist - along with Lenin, Bogdanov was the leader of ...
BORIS ALEKSEEVICH Myasoyedov
doaj
Advanced Science, EarlyView.CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He +17 more
wiley +1 more source
ALEXANDER VASILIEVICH CHAYANOV. IMMORTAL IDEAS OF A GREAT SCIENTIST
Мир новой экономики, 2018 Continuing the tradition, in the next life story the author tells about another great scientist - Alexander Vasilevich Chayanov.Complex fate awaited this scientist intellectual - he survived several arrests and deportations during which he continued to ...
BORIS ALEKSEEVICH Myasoyedov
doaj
Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source
Iranian Journal of Information Processing & Management, 2012 The present study was carried out with the aim of investigating factors affecting utilization of information technology by students of agriculture. A survey approach was used in this study and a questionnaire was developed to gather the data.
Masoud Rezaei, Davood Mohammadi
doaj