Results 141 to 150 of about 20,184,694 (295)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Structural Potting of Large Aeronautic Honeycomb Panels: End-Effector Design and Test for Automated Manufacturing. [PDF]

Materials (Basel), 2022
Campos C, Casarejos E, Segade A.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Lab on an end: Micromanipulation using the acoustohydrodynamic pillar array as an end effector. [PDF]

Proc Natl Acad Sci U S A
Chen Z, Bai C, Liu F, Huang Q, Fukuda T, Arai T, Liu X.   +6 more
europepmc   +1 more source

Switch controllers of an n-link revolute manipulator with a prismatic end-effector for landmark navigation. [PDF]

PeerJ Comput Sci, 2022
Chand R, Chand RP, Kumar SA.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

End-Effector Robot-Assisted Gait Training in Quadruple Amputees: Two Case Reports. [PDF]

Ann Rehabil Med
Kim Y, Oh Y, Shin S, Oh D, Cho SI, Jeong J, Yoo J.   +6 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Feasibility study of the assessment of upper limb function in children with Unilateral Cerebral Palsy using an end-effector robotic device. [PDF]

J Neuroeng Rehabil
Barzacchi V, Beani E, Filogna S, Sgherri G, Menici V, Marsanich G, Mazzoleni S, Cioni G, Sgandurra G.   +8 more
europepmc   +1 more source

A Constant-Force End-Effector With Online Force Adjustment for Robotic Ultrasonography. [PDF]

IEEE Robot Autom Lett, 2021
Bao X, Wang S, Housden R, Hajnal J, Rhode K.   +4 more
europepmc   +1 more source