Results 81 to 90 of about 679,466 (304)

Stem cell therapy for hepatocellular carcinoma and end-stage liver disease

Journal of the Egyptian National Cancer Institute, 2023
Hepatocellular carcinoma (HCC) is a major health problem worldwide, especially for patients who are suffering from end-stage liver disease (ESLD). The ESLD is considered a great challenge for clinicians due to the limited chance for liver transplantation,
Mona S. Abdellateif, Abdel-Rahman N. Zekri   +1 more
doaj   +1 more source

Changing perspectives on liver transplantation in 1988. [PDF]

, 1988
After liver transplantation for cancer, there is a high incidence of disease recurrence within 18 to 36 months for most tumors, although there are a small number of long-term survivors.
Gordon, RD, Starzl, TE
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Clinical applications of the Model for End-Stage Liver Disease (MELD) in hepatic medicine

Hepatic Medicine: Evidence and Research, 2013
Tsang Lau, Jawad AhmadDivision of Liver Diseases, Mount Sinai School of Medicine, New York, USAAbstract: The Model for End-Stage Liver Disease (MELD) score incorporates serum bilirubin, creatinine, and the international normalized ratio (INR) into a ...
Lau T, Ahmad J
doaj  

Implementation of a living donor liver transplantation program in the Republic of Uzbekistan: a report of the first 40 cases

Clinical Transplantation and Research
Background : Living donor liver transplantation (LDLT) is an effective treatment for patients with end-stage liver disease. This study was performed to evaluate the outcomes of the initial series of LDLT procedures performed in the Republic of Uzbekistan
Konstantin Semash, Timur Dzhanbekov, Mirshavkat Akbarov, Miraziz Mirolimov, Azimjon Usmonov, Navruz Razzokov, Ziyodulla Primov, Temurbek Gaybullaev, Sardor Yigitaliev   +8 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Model for End-Stage Liver Disease, Model for Liver Transplantation Survival and Donor Risk Index as predictive models of survival after liver transplantation in 1,006 patients

Clinics, 2015
OBJECTIVES: Liver transplantation has not increased with the number of patients requiring this treatment, increasing deaths among those on the waiting list.
Elisa Maria de Camargo Aranzana, Adriana Zuolo Coppini, Maurício Alves Ribeiro, Paulo Celso Bosco Massarollo, Luiz Arnaldo Szutan, Fabio Gonçalves Ferreira   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Clinical Significance of Serum Adiponectin and Resistin Levels in Liver Cirrhosis

Annals of Hepatology, 2018
Introduction. Adiponectin and resistin levels are increased in patients with cirrhosis, but it prognostic significance is unknown. We sought to investigate the factors associated with adiponectin and resistin levels and its clinical significance in ...
Telma Erotides da Silva, Mariana Costa-Silva, Carina G. Correa, Giovana Denardin, Maria L. Ayres Alencar, Mara S. Pacheco Honório Coelho, Letícia Muraro-Wildner, Maria Luiza-Bazzo, David A. González-Chica, Esther Buzaglo Dantas-Correa, Janaína L. Narciso-Schiavon, Leonardo de Lucca Schiavon   +11 more
doaj   +1 more source

Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease [PDF]

, 2015
Hepatitis B virus (HBV) infection is a dynamic state of interactions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B (CHB) infection have shown an association between active viral replication and adverse
Farinati, Fabio, Gottardo, G, Rodr\uedguez Castro, K, Russo, FRANCESCO PAOLO, Scribano, L, Vanin, V   +5 more
core   +1 more source