Results 131 to 140 of about 66,863,659 (305)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
SSRN Electronic JournalLipreading is the task of decoding text from the movement of a speaker’s mouth. This research presents the development of an advanced end-to-end lipreading system. Leveraging deep learning architectures and multimodal fusion techniques, the proposed system interprets spoken language solely from visual cues, such as lip movements.
null Jishnu T S, Anju Antony
openaire +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Development of end-to-end tests and extension of the continuous integration system of a web application [PDF]
reservedIl presente documento descrive il progetto di stage universitario svolto dal laureando Vanni Giachin nella primavera 2015, presso la sede di Vicenza dell'azienda Qlik, con l'obiettivo di sviluppare una serie di test end-to-end per il software ...
GIACHIN, VANNI
core
End Conscription Campaign [PDF]
, 2017 A flyer explaining the beliefs and positions of the End Conscription Campaign.https://digitalcommons.colum.edu/ecc/1016/thumbnail ...
End Conscription Campaign
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Journal of Economy and TechnologyObjective: Little research has been done on the user-centered document ranking approach, especially in a crowdsourcing chart review environment. As the starting point of designing and implementing the next generation of Electronic Medical Record (EMR ...
Cheng Ye, Daniel Fabbri
doaj +1 more source