Results 121 to 130 of about 66,863,659 (305)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
BMJ Global HealthIn 2005, the governments of Bangladesh, India and Nepal, in partnership with the WHO, started the Kala-azar Elimination Programme (KEP) to reduce the incidence of visceral leishmaniasis to below 1 new case in 10 000 population. The target was achieved by
Ermias Diro +3 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design of automated End-to-End tests for web applications: framework analysis and implementation [PDF]
reservedQuesto documento descrive il lavoro svolto durante il periodo di stage presso l'azienda Sanmarco Informatica S.p.A. Il tirocinio ha avuto come obiettivo principale la progettazione e lo sviluppo di un sistema di automazione dei test End-to-End ...
CAMPESE, MARTINA
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
A Routing Algorithm to Guarantee End-to-End Delay for Sensor Networks [PDF]
, 2013 In this paper, we state the phenomenon of Pay Bursts Only Once in communication networks and propose a routing algorithm to guarantee endto- end delay.
Yu HB(于海斌) +3 more
core
An end‐to‐end infant brain parcellation pipeline
Intelligent MedicineObjective: Accurate infant brain parcellation is crucial for understanding early brain development; however, it is challenging due to the inherent low tissue contrast, high noise, and severe partial volume effects in infant magnetic resonance images ...
Limei Wang +4 more
doaj +1 more source